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Influence of Ventricular Fibrillation Duration on Defibrillation Energy in Dogs Using Bidirectional Pulse Discharges

The automatic implantable defibrillator device typically discharges 5–30 seconds after detection of ventricular fibrillation. To investigate the importance of the duration of ventricular fibrillation on defibrillation, the effects of ventricular fibrillation durations of 5, 15, and 30 seconds on the...

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Bibliographic Details
Published in:Pacing and clinical electrophysiology 1988-09, Vol.11 (9), p.1315-1323
Main Authors: ECHT, DEBRA S., BARBEY, JEAN T., BLACK, JAMES N.
Format: Article
Language:English
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Summary:The automatic implantable defibrillator device typically discharges 5–30 seconds after detection of ventricular fibrillation. To investigate the importance of the duration of ventricular fibrillation on defibrillation, the effects of ventricular fibrillation durations of 5, 15, and 30 seconds on the energy requirements for successful internal defibrillation were compared in 15 dosed chest dogs with internal electrodes. The electrode configuration utilized a transvenous right heart catheter with two electrodes and a precordial subcutaneous patch electrode, with a single bidirectional pulse discharged between the distal catheter electrode and the proximal catheter and patch electrodes. Curves of energy vs. percentage of successful defibrillation were constructed and logistic regression was used to derive 90% and 50% successful energy doses (ED90 and ED50). The mean ventricular fibrillation activation interval just prior to defibrillation was determined from discrete RV endocardial electrograms. Four dogs died during testing, all because of inability to defibrillate after 30 s of ventricular fibrillation. In the remaining 11 dogs, the ED90 increased from (mean ± SD) 27 ± 13J at 5 s to 41 ± 14J at 30 s (p < .01). The mean ventricular fibrillation activation interval decreased from 107 ± 21 ms at 5 s to 95 ± 18 ms at 30 s (p < .01). In conclusion, the energy required for internal defibrillation in dogs using this electrode configuration increases with longer durations of ventricular fibrillation, and is associated with more rapid ventricular fibrillation activation intervals.
ISSN:0147-8389
1540-8159
DOI:10.1111/j.1540-8159.1988.tb03994.x