Lymphocyte muscarinic cholinergic activity and PGE2 involvement in experimental Trypanosoma cruzi infection

In this paper, we demonstrated that the production of PGE2 by CD8+ T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethal Trypanosoma cruzi CA-1 strain could enhance resistance to infection. Treatment in vivo with either atro...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1996-11, Vol.81 (2), p.122-128
Main Authors: STERIN-BORDA, L, GORELIK, G, GOREN, N, GONZALEZ CAPPA, S, CELENTANO, A. M, BORDA, E
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
AIDS/HIV
Animals
Atropine - pharmacology
Biological and medical sciences
CD8-Positive T-Lymphocytes - chemistry
Cell Membrane - parasitology
Chagas Disease - blood
Chagas Disease - immunology
Dinoprostone - blood
Dinoprostone - pharmacology
Experimental protozoal diseases and models
Immunity, Innate
Immunoglobulin G - metabolism
Infectious diseases
Male
Medical sciences
Mice
Mice, Inbred BALB C
Muscarinic Antagonists - pharmacology
Parasitic diseases
Protozoal diseases
Receptors, Cholinergic - immunology
Receptors, Cholinergic - metabolism
Receptors, Muscarinic - immunology
Receptors, Muscarinic - metabolism
T-Lymphocytes - metabolism
Trypanosoma cruzi - isolation & purification
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Summary:In this paper, we demonstrated that the production of PGE2 by CD8+ T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethal Trypanosoma cruzi CA-1 strain could enhance resistance to infection. Treatment in vivo with either atropine or cyclooxygenase inhibitors enhanced mortality rates and parasitemia of mice infected with T. cruzi CA-1 strain. The mechanism by which CD8+ T lymphocytes released PGE2 appears to involve the activation of the cells by circulating IgG present in mice infected with T. cruzi CA-1 strain. Binding of these antibodies to mAChR on CD8+ T lymphocytes triggered the release of large amounts of PGE2. The results point to a role of serum antibodies against mAChR in the protection of T. cruzi infection. The prostanoid acting as an immunomodulator contributed to the maintenance of the chronic course of experimental Chagas disease.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1996.0167