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rRNA TRANSCRIPTION AND GROWTH RATE-DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI
The synthesis of ribosomal RNA is the rate-limiting step in ribosome synthesis in bacteria. There are multiple mechanisms that determine the rate of rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional strength and for regulation in response to nutritional conditions and amin...
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| Published in: | Annual review of microbiology 1996-01, Vol.50 (1), p.645-677 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a638t-59475afbc27bc78aa6607d3a5e01b40228cdb36699eeab2100d6dea532de833f3 |
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| cites | cdi_FETCH-LOGICAL-a638t-59475afbc27bc78aa6607d3a5e01b40228cdb36699eeab2100d6dea532de833f3 |
| container_end_page | 677 |
| container_issue | 1 |
| container_start_page | 645 |
| container_title | Annual review of microbiology |
| container_volume | 50 |
| creator | Gourse, Richard L Gaal, Tamas Bartlett, Michael S Appleman, J. Alex Ross, Wilma |
| description | The synthesis of ribosomal RNA is the rate-limiting step in ribosome
synthesis in bacteria. There are multiple mechanisms that determine the rate of
rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional
strength and for regulation in response to nutritional conditions and amino
acid availibility. Strength derives in part from an extended RNA polymerase
(RNAP) recognition region involving at least two RNAP subunits, in part from
activation by a transcription factor and in part from modification of the
transcript by a system that prevents premature termination. Regulation derives
from at least two mechanistically distinct systems, growth rate-dependent
control and stringent control. The mechanisms contributing to rRNA
transcription work together and compensate for one another when individual
systems are rendered inoperative. |
| doi_str_mv | 10.1146/annurev.micro.50.1.645 |
| format | article |
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synthesis in bacteria. There are multiple mechanisms that determine the rate of
rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional
strength and for regulation in response to nutritional conditions and amino
acid availibility. Strength derives in part from an extended RNA polymerase
(RNAP) recognition region involving at least two RNAP subunits, in part from
activation by a transcription factor and in part from modification of the
transcript by a system that prevents premature termination. Regulation derives
from at least two mechanistically distinct systems, growth rate-dependent
control and stringent control. The mechanisms contributing to rRNA
transcription work together and compensate for one another when individual
systems are rendered inoperative.</description><identifier>ISSN: 0066-4227</identifier><identifier>EISSN: 1545-3251</identifier><identifier>DOI: 10.1146/annurev.micro.50.1.645</identifier><identifier>PMID: 8905094</identifier><identifier>CODEN: ARMIAZ</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Bacteria ; Bacteriology ; Biological and medical sciences ; DNA, Bacterial - chemistry ; E coli ; Escherichia coli ; Escherichia coli - genetics ; Escherichia coli - growth & development ; feedback ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Bacterial ; Genetic aspects ; Genetic regulation ; Genetic transcription ; Genetics ; Guanosine Pentaphosphate - metabolism ; Microbiology ; Models, Genetic ; Nucleic Acid Conformation ; promoter ; Promoter Regions, Genetic ; regulation of gene expression ; Ribonucleic acid ; Ribosomal RNA ; Ribosomes - metabolism ; RNA ; RNA polymerase ; RNA, Ribosomal - biosynthesis ; Terminator Regions, Genetic ; transcription mechanisms ; Transcription, Genetic</subject><ispartof>Annual review of microbiology, 1996-01, Vol.50 (1), p.645-677</ispartof><rights>Copyright © 1996 by Annual Reviews Inc. All rights reserved</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 Annual Reviews, Inc.</rights><rights>Copyright Annual Reviews, Inc. 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a638t-59475afbc27bc78aa6607d3a5e01b40228cdb36699eeab2100d6dea532de833f3</citedby><cites>FETCH-LOGICAL-a638t-59475afbc27bc78aa6607d3a5e01b40228cdb36699eeab2100d6dea532de833f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.micro.50.1.645?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.micro.50.1.645$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3250730$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8905094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gourse, Richard L</creatorcontrib><creatorcontrib>Gaal, Tamas</creatorcontrib><creatorcontrib>Bartlett, Michael S</creatorcontrib><creatorcontrib>Appleman, J. Alex</creatorcontrib><creatorcontrib>Ross, Wilma</creatorcontrib><title>rRNA TRANSCRIPTION AND GROWTH RATE-DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI</title><title>Annual review of microbiology</title><addtitle>Annu Rev Microbiol</addtitle><description>The synthesis of ribosomal RNA is the rate-limiting step in ribosome
synthesis in bacteria. There are multiple mechanisms that determine the rate of
rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional
strength and for regulation in response to nutritional conditions and amino
acid availibility. Strength derives in part from an extended RNA polymerase
(RNAP) recognition region involving at least two RNAP subunits, in part from
activation by a transcription factor and in part from modification of the
transcript by a system that prevents premature termination. Regulation derives
from at least two mechanistically distinct systems, growth rate-dependent
control and stringent control. The mechanisms contributing to rRNA
transcription work together and compensate for one another when individual
systems are rendered inoperative.</description><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>DNA, Bacterial - chemistry</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - growth & development</subject><subject>feedback</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Genetic aspects</subject><subject>Genetic regulation</subject><subject>Genetic transcription</subject><subject>Genetics</subject><subject>Guanosine Pentaphosphate - metabolism</subject><subject>Microbiology</subject><subject>Models, Genetic</subject><subject>Nucleic Acid Conformation</subject><subject>promoter</subject><subject>Promoter Regions, Genetic</subject><subject>regulation of gene expression</subject><subject>Ribonucleic acid</subject><subject>Ribosomal RNA</subject><subject>Ribosomes - metabolism</subject><subject>RNA</subject><subject>RNA polymerase</subject><subject>RNA, Ribosomal - biosynthesis</subject><subject>Terminator Regions, Genetic</subject><subject>transcription mechanisms</subject><subject>Transcription, Genetic</subject><issn>0066-4227</issn><issn>1545-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkl-LnDAUxUNp2c5u-xFapJQ-1Wn-mBjZJ-u4M8JUF3UpfQpR4-Li6DTqtv32zezIFsrAkIfAvb-Tk8s9ALxHcImQw77Irpu0elzumlL3S2qqS-bQF2CBqENtgil6CRYQMmY7GLuvweUwPEAIHRd6F-CCe5BCz1kAqdPYt_LUj7MgjW7zKIktP15Z6zT5nm-s1M9DexXehvEqjHMrDdd3W_8JSm6sNPqaZMm30Mp-xPkmzKLMimIrzIJNmEbBJvKtINlGb8CrWraDejvfV-DuJsyDjb1N1lHgb23JCB9t6jkulXVRYrcoXS4lY9CtiKQKosKBGPOyKghjnqeULDCCsGKVkpTgSnFCanIFPh3f3ev-56SGUeyaoVRtKzvVT4NwOTUqxs-CiLoeRh414If_wId-0p0ZQmBIOYcIeQb6fITuZatE09X9qGV5rzqlZdt3qm5M2UfcY4TiA26fwM2plNnkKZ4debPlYdCqFnvd7KT-IxAUhyCIOQjiKQiCmqowQTDCd_Pnp2KnqmfZvHnT_zj35VDKttayK5vhGTMBgi6BBrs-Ygcb2RqjRv36h502F_uqFuPv8Zz6zAh_AfVS4YY</recordid><startdate>19960101</startdate><enddate>19960101</enddate><creator>Gourse, Richard L</creator><creator>Gaal, Tamas</creator><creator>Bartlett, Michael S</creator><creator>Appleman, J. Alex</creator><creator>Ross, Wilma</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19960101</creationdate><title>rRNA TRANSCRIPTION AND GROWTH RATE-DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI</title><author>Gourse, Richard L ; Gaal, Tamas ; Bartlett, Michael S ; Appleman, J. Alex ; Ross, Wilma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a638t-59475afbc27bc78aa6607d3a5e01b40228cdb36699eeab2100d6dea532de833f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>DNA, Bacterial - chemistry</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - growth & development</topic><topic>feedback</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Genetic aspects</topic><topic>Genetic regulation</topic><topic>Genetic transcription</topic><topic>Genetics</topic><topic>Guanosine Pentaphosphate - metabolism</topic><topic>Microbiology</topic><topic>Models, Genetic</topic><topic>Nucleic Acid Conformation</topic><topic>promoter</topic><topic>Promoter Regions, Genetic</topic><topic>regulation of gene expression</topic><topic>Ribonucleic acid</topic><topic>Ribosomal RNA</topic><topic>Ribosomes - metabolism</topic><topic>RNA</topic><topic>RNA polymerase</topic><topic>RNA, Ribosomal - biosynthesis</topic><topic>Terminator Regions, Genetic</topic><topic>transcription mechanisms</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gourse, Richard L</creatorcontrib><creatorcontrib>Gaal, Tamas</creatorcontrib><creatorcontrib>Bartlett, Michael S</creatorcontrib><creatorcontrib>Appleman, J. 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Alex</au><au>Ross, Wilma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>rRNA TRANSCRIPTION AND GROWTH RATE-DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI</atitle><jtitle>Annual review of microbiology</jtitle><addtitle>Annu Rev Microbiol</addtitle><date>1996-01-01</date><risdate>1996</risdate><volume>50</volume><issue>1</issue><spage>645</spage><epage>677</epage><pages>645-677</pages><issn>0066-4227</issn><eissn>1545-3251</eissn><coden>ARMIAZ</coden><abstract>The synthesis of ribosomal RNA is the rate-limiting step in ribosome
synthesis in bacteria. There are multiple mechanisms that determine the rate of
rRNA synthesis.Ribosomal RNA promoter sequences have evolved for exceptional
strength and for regulation in response to nutritional conditions and amino
acid availibility. Strength derives in part from an extended RNA polymerase
(RNAP) recognition region involving at least two RNAP subunits, in part from
activation by a transcription factor and in part from modification of the
transcript by a system that prevents premature termination. Regulation derives
from at least two mechanistically distinct systems, growth rate-dependent
control and stringent control. The mechanisms contributing to rRNA
transcription work together and compensate for one another when individual
systems are rendered inoperative.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>8905094</pmid><doi>10.1146/annurev.micro.50.1.645</doi><tpages>33</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4227 |
| ispartof | Annual review of microbiology, 1996-01, Vol.50 (1), p.645-677 |
| issn | 0066-4227 1545-3251 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78521068 |
| source | Annual Reviews |
| subjects | Bacteria Bacteriology Biological and medical sciences DNA, Bacterial - chemistry E coli Escherichia coli Escherichia coli - genetics Escherichia coli - growth & development feedback Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genetic aspects Genetic regulation Genetic transcription Genetics Guanosine Pentaphosphate - metabolism Microbiology Models, Genetic Nucleic Acid Conformation promoter Promoter Regions, Genetic regulation of gene expression Ribonucleic acid Ribosomal RNA Ribosomes - metabolism RNA RNA polymerase RNA, Ribosomal - biosynthesis Terminator Regions, Genetic transcription mechanisms Transcription, Genetic |
| title | rRNA TRANSCRIPTION AND GROWTH RATE-DEPENDENT REGULATION OF RIBOSOME SYNTHESIS IN ESCHERICHIA COLI |
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