Cytokine-mediated Inhibition of Erythropoietin Synthesis by Dexamethasone

The effect of inflammatory cytokines on the in‐vitro synthesis of erythropoietin by HepG2 cells was evaluated. Monocyte‐conditioned medium, and the cytokines interleukin‐1β, interleukin‐6 and tumour necrosis factor‐α all reduced synthesis of erythropoietin. The steroidal anti‐inflammatory drug, dexa...

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Published in:Journal of pharmacy and pharmacology 1996-09, Vol.48 (9), p.971-974
Main Authors: Leng, H. M. J., Kidson, S. H., Keraan, M. M., Randall, G. W., Folb, P. I.
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cell Line
Culture Media, Conditioned
Cytokines - pharmacology
Dexamethasone - pharmacology
Erythropoietin - biosynthesis
Humans
Indicators and Reagents
Interleukin-1 - pharmacology
Interleukin-6 - pharmacology
Medical sciences
Monocytes - physiology
Pharmacology. Drug treatments
Tumor Necrosis Factor-alpha - pharmacology
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Summary:The effect of inflammatory cytokines on the in‐vitro synthesis of erythropoietin by HepG2 cells was evaluated. Monocyte‐conditioned medium, and the cytokines interleukin‐1β, interleukin‐6 and tumour necrosis factor‐α all reduced synthesis of erythropoietin. The steroidal anti‐inflammatory drug, dexamethasone, did not affect cytokine‐mediated erythropoietin inhibition. Dexamethasone did cause a reduction in the secretion of erythropoietin inhibitory cytokines from monocytes. These results point to a possible therapeutic approach in the treatment of anaemia caused by suppression of erythropoietin synthesis by monocytic cytokines.
ISSN:0022-3573
2042-7158
DOI:10.1111/j.2042-7158.1996.tb06015.x