Influence of depression on cognitive functioning in Fragile X females

We sought to determine the frequency of a history of major depression in women with Fragile X syndrome. In addition, we attempted to disentangle the cognitive effects of major depression from those of Fragile X syndrome. Thirty-seven mothers of developmentally delayed children (Fragile X syndrome: n...

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Bibliographic Details
Published in:Psychiatry research 1996-09, Vol.64 (2), p.97-104
Main Authors: Thompson, Nora M, Rogeness, Graham A, McClure, Erin, Clayton, Robert, Johnson, Chris
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Cognition Disorders - complications
Cognition Disorders - diagnosis
Depression
Depressive Disorder - complications
Depressive Disorder - diagnosis
Female
Fragile X Syndrome - genetics
Genetic disorders
Humans
Medical sciences
Memory
Middle Aged
Mood disorders
Neuropsychological Tests
Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sex Factors
Visuospatial performance
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Summary:We sought to determine the frequency of a history of major depression in women with Fragile X syndrome. In addition, we attempted to disentangle the cognitive effects of major depression from those of Fragile X syndrome. Thirty-seven mothers of developmentally delayed children (Fragile X syndrome: n = 18; comparison group n = 19), matched for age, educational level, and socioeconomic status, were administered psychiatric and neuropsychological measures. Women with Fragile X syndrome had a higher frequency of lifetime diagnosis of major depressive disorder (78%) than the comparison group (37%). Mild impairment was seen on visuospatial construction and memory tasks in women with Fragile X syndrome, while women with depression showed subtle deficits in several aspects of visuospatial perception and learning. There was no interaction of Fragile X syndrome and depression in their influence on cognition. The results underscore the importance of considering the influence of depression on cognitive performance in studies of genetic disorders.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(96)02785-0