Experimental systemic cryptococcosis in SCID mice

The susceptibility of severe combined immune deficiency (SCID) mice to experimental systemic cryptococcosis was studied. SCID mice were at least 16-fold more susceptible to lethal infection than were immunocompetent control mice (P < 0·001). Histological assessment showed that control mice respon...

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Bibliographic Details
Published in:Journal of medical and veterinary mycology 1996, Vol.34 (5), p.331-335
Main Authors: Clemons, K.V., Azzi, R., Stevens, D.A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cryptococcosis - drug therapy
Cryptococcosis - immunology
Cryptococcosis - physiopathology
Cryptococcus neoformans
Cryptococcus neoformans - growth & development
Cryptococcus neoformans - isolation & purification
Disease Susceptibility
Experimental mycoses and models
Female
Fluconazole - therapeutic use
Immunity, Cellular
Infectious diseases
Inflammation
Medical sciences
Mice
Mice, Inbred ICR
Mice, Inbred Strains
Mice, SCID
Mycoses
Species Specificity
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Summary:The susceptibility of severe combined immune deficiency (SCID) mice to experimental systemic cryptococcosis was studied. SCID mice were at least 16-fold more susceptible to lethal infection than were immunocompetent control mice (P < 0·001). Histological assessment showed that control mice responded with a granulomatous inflammatory response, whereas SCID mice showed no evidence of a cellular host response. In a therapeutic study, 5 mg kg-1 day-1 of fluconazole caused a significant reduction in the infectious burden in the spleen, liver, kidney and lungs of treated mice compared with no treatment. These results indicate that a model of systemic cryptococcosis with meningitis in SCID mice may have utility in the study of immunology and therapy of this disease in the severely immunocompromised host.
ISSN:1369-3786
0268-1218
1460-2709
DOI:10.1080/02681219680000561