Re-Entrant Activity and Its Control in a Model of Mammalian Ventricular Tissue

We characterize the meander of re-entrant excitation in a model of a sheet of mammalian ventricular tissue, and its control by resonant drift under feedback driven stimulation. The Oxsoft equations for excitability in a guinea pig single ventricular cell were incorporated in a two dimensional reacti...

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Bibliographic Details
Published in:Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1996-10, Vol.263 (1375), p.1373-1382
Main Authors: Biktashev, V. N., Holden, A. V.
Format: Article
Language:English
Subjects:
Action potentials
Amplitude
Animals
Body tissues
Electric potential
Feedback control
Heart Conduction System - physiology
Kinetics
Mammals
Models, Theoretical
Myocardial Contraction - physiology
Plane waves
Resonance
Trajectories
Ventricular Function
Wave velocity
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Summary:We characterize the meander of re-entrant excitation in a model of a sheet of mammalian ventricular tissue, and its control by resonant drift under feedback driven stimulation. The Oxsoft equations for excitability in a guinea pig single ventricular cell were incorporated in a two dimensional reaction-diffusion system to model homogeneous, isotropic tissue with a plane wave conduction velocity of 0.35 m s-1. Re-entrant spiral wave solutions have a spatially extended transient motion (linear core) that settles down into rotation with an irregular period of 100-110 ms around an irregular, multi-lobed spiky core. In anisotropic tissue this would appear as a linear conduction block. The typical velocity of drift of the spiral wave induced by low amplitude resonant forcing is 0.4 cm s-1.
ISSN:0962-8452
1471-2954
DOI:10.1098/rspb.1996.0201