Systemic pressor response during hindlimb ischemia is inversely related to femoral artery pressure and fractional inspired oxygen

• Published in: Surgery 1996-11, Vol.120 (5), p.838-844
• Main Authors: Zwemer, Charles F., Giglia, Joseph S., Zelenock, Gerald B., D'Alecy, Louis G.
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - physiology; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dogs; Femoral Artery - physiopathology; Hematocrit; Hemodynamics - physiology; Hindlimb - blood supply; Hypertension - physiopathology; Hypotension - physiopathology; Ischemia - blood; Ischemia - physiopathology; Male; Medical sciences; Oxygen - physiology; Reflex - physiology; Respiration - physiology
• ISSN: 0039-6060; 1532-7361
• DOI: 10.1016/S0039-6060(96)80092-4

Background. Delayed-onset reflex increases in mean arterial pressure (MAP) occur during clamping of the infrarenal aorta. This study investigated the afferent limb of the reflex by independently altering femoral artery blood pressure (FBP) or fractional concentration of inspired oxygen (Fio 2) while monitoring systemic arterial blood pressure. Methods. The infrarenal aorta was divided, and an occlusive roller pump delivered incremental flow to the distal aorta thus controlling FBP. In six dogs the FBP was reduced in random order to 50, 40, 30, 20, and 10 mm Hg and held constant for 30 minutes. In another six dogs the FBP was held at 20 mm Hg, whereas the Fio 2 was randomly varied among 0.13, 0.21, and 1.0 for 30-minute intervals. Results. Under these conditions MAP was significantly and inversely correlated with FBP (MAP was 172±8 mm Hg when FBP was 10 mm Hg, p