Dopaminergic control of TSH secretion in endogenous depression

To evaluate whether the inhibitory control exerted by endogenous dopamine on thyroid-stimulating hormone (TSH) secretion is altered in patients with major depressive disorder, 11 depressed patients and 9 normal controls were tested with the dopaminergic receptor antagonist domperidone (10 or 20 mg i...

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Bibliographic Details
Published in:Psychiatry research 1988-09, Vol.25 (3), p.277-282
Main Authors: Marchesi, Carlo, Chiodera, Paolo, De Risio, Carlo, Dassò, Leonardo, Govi, Anna Maria, De Ferri, Alberto, Piagneri, Beppino, Minelli, Roberta, Bianconi, Lina, Gnudi, Angelo, Coiro, Vittorio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Brain - physiopathology
Depressive Disorder - physiopathology
Domperidone
dopamine
Endogenous depression
Female
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Dopamine - physiology
Techniques and methods
thyroid-stimulating hormone
Thyrotropin - blood
Thyrotropin-Releasing Hormone
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Summary:To evaluate whether the inhibitory control exerted by endogenous dopamine on thyroid-stimulating hormone (TSH) secretion is altered in patients with major depressive disorder, 11 depressed patients and 9 normal controls were tested with the dopaminergic receptor antagonist domperidone (10 or 20 mg i.v.). The administration of domperidone induced a significant increase in circulating TSH levels in the normal controls, but not in the depressed patients. These data excluded the possibility that the dopaminergic inhibition of TSH secretion is enhanced in depression. To establish whether domperidone failure was due to reduced dopaminergic tone, domperidone was administered before stimulation of TSH secretion with thyrotropin-releasing hormone (TRH) (200 μg i.v.). The TSH response to TRH was significantly lower in the depressed than in the control subjects, regardless of domperidone priming. However, in both groups domperidone enhanced the TSH-induced TSH release by 50%. These data suggest that the dopaminergic control of TSH secretion is not altered in patients with endogenous depression and that a reduced capacity of the pituitary to secrete TSH might be responsible for the reduced TSH responsiveness to TRH and domperidone.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(88)90098-4