COMPARING MEAN LEVELS OF TOTAL CHOLESTEROL FROM VISIT 2 OF THE LIPID RESEARCH CLINICS PREVALENCE STUDY WITH THE SECOND NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY

Mean levels of total cholesterol by sex and age were compared between groups of whites in visit 2 of the Lipid Research Clinics Program Prevalence Study and in the second National Health and Nutrition Examination Survey (NHANES II). NHANES II estimates were found to be higher than comparable visit 2...

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Bibliographic Details
Published in:American journal of epidemiology 1988-11, Vol.128 (5), p.1038-1053
Main Authors: KALSBEEK, WILLIAM D., KRAL, KENNETH M., WALLACE, ROBERT B., RIFKIND, BASIL M.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
cholesterol
Cholesterol - blood
Epidemiologic Methods
Female
Health Surveys
Hormones - administration & dosage
Humans
lipids
Lipids - blood
Male
Medical sciences
Middle Aged
Plasma - analysis
Public health. Hygiene-occupational medicine
Quality Control
Random Allocation
Research Design
Seasons
Sex Factors
United States
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Summary:Mean levels of total cholesterol by sex and age were compared between groups of whites in visit 2 of the Lipid Research Clinics Program Prevalence Study and in the second National Health and Nutrition Examination Survey (NHANES II). NHANES II estimates were found to be higher than comparable visit 2 estimates by 3–14 mg/dl for males and by 11–21 mg/dl for females. Adjustment for the use of differing components of blood in making the lipid determinations in the two studies (plasma in visit 2 and serum in NHANES II) reduced the original differences by roughly one half. Other adjustments—for operational differences among laboratories that performed the blood sample analysis in the two studies, for educational differences in the study populations, and for inclusion of data from a Toronto clinic in the visit 2 data—were collectively found to explain most of the remaining differences between visit 2 and NHANES II, especially for males.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a115048