Nonuniform recovery of excitability in the left ventricle

The purpose of this study was to determine left ventricular activation, dispersion of refractoriness, and total recovery time in patients with coronary artery disease and ventricular tachycardia and in patients with the long QT syndrome and to compare these patients with a group of normal patients....

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1988-12, Vol.78 (6), p.1365-1372
Main Authors: VASSALLO, J. A, CASSIDY, D. M, KINDWALL, K. E, MARCHLINSKI, F. E, JOSEPHSON, M. E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Arrhythmias, Cardiac - physiopathology
Biological and medical sciences
Coronary Disease - physiopathology
Electrocardiography. Vectocardiography
Electrodiagnosis. Electric activity recording
Electrophysiology
Endocardium - physiopathology
Female
Heart - physiopathology
Heart Conduction System - physiopathology
Heart Ventricles
Humans
Investigative techniques, diagnostic techniques (general aspects)
Long QT Syndrome - physiopathology
Male
Medical sciences
Middle Aged
Reference Values
Tachycardia, Supraventricular - physiopathology
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Summary:The purpose of this study was to determine left ventricular activation, dispersion of refractoriness, and total recovery time in patients with coronary artery disease and ventricular tachycardia and in patients with the long QT syndrome and to compare these patients with a group of normal patients. Left ventricular endocardial catheter mapping and left ventricular refractory period determination were performed in 18 patients. Group 1 consisted of seven patients with no heart disease and no arrhythmia; group 2 consisted of six patients with previous infarction and sustained ventricular tachycardia; and group 3 consisted of five patients with prolonged QT interval and previous cardiac arrest. Total left ventricular endocardial activation was significantly longer in group 2 (75 +/- 23 msec, mean +/- SD) compared with group 1 (34 +/- 9 msec, p less than 0.01) and group 3 (42 +/- 5 msec, p less than 0.05). Dispersion of refractoriness was significantly greater in group 3 (87 +/- 27 msec) than in group 1 (40 +/- 14 msec, p less than 0.01) and group 2 (53 +/- 14 msec, p less than 0.05). Dispersion of total recovery time was significantly greater in group 2 (90 +/- 30 msec) than in group 1 (52 +/- 14 msec, p less than 0.05) as well as group 3 (114 +/- 43 msec) compared with group 1 (p less than 0.01).
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.78.6.1365