Purified urinary follicle stimulating hormone induces different hormone profiles compared with menotrophins, dependent upon the route of administration and endogenous luteinizing hormone activity

The effects of treatment of patients with gonadotrophin-releasing hormone analogue (GnRHa) combined with purified follicle stimulating hormone (FSH) for in-vitro fertilization (IVF) were investigated in detail to determine the influences of different administration routes and the degree of suppressi...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1996-09, Vol.11 (9), p.1854-1858
Main Authors: Fleming, R., Chung, C.C., Yates, R.W.S., Coutts, J.R.T.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Female
Follicle Stimulating Hormone - administration & dosage
Follicle Stimulating Hormone - pharmacology
Follicle Stimulating Hormone - urine
Follicular Phase - blood
Gynecology. Andrology. Obstetrics
hormone profile
Hormones - blood
Humans
Injections, Intramuscular
Injections, Subcutaneous
Luteinizing Hormone - blood
Medical sciences
menotropbins
Menotropins - administration & dosage
Menotropins - pharmacology
Osmolar Concentration
purified urinary FSH
Sterility. Assisted procreation
Time Factors
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Summary:The effects of treatment of patients with gonadotrophin-releasing hormone analogue (GnRHa) combined with purified follicle stimulating hormone (FSH) for in-vitro fertilization (IVF) were investigated in detail to determine the influences of different administration routes and the degree of suppression of luteinizing hormone (LH). Responses to exogenous gonadotrophins were studied in infertile women (n = 60) with normal menstrual rhythm whose endogenous gonadotrophin activity was suppressed using a GnRHa in a long protocol. They were randomized to receive i.m. administration of human menopausal gonadotrophins (HMGim, Pergonal) or purified follicle stimulating hormone (FSH, Metrodin High Purity) administered either i.m. (MHPim) or s.c (MHPsc). Responses were assessed by measuring plasma FSH, LH, oestradiol, testosterone and progesterone. After stimulation day 4, the MHPsc group showed significantly higher circulating concentrations of FSH than either the MHPim or HMGim group. However, the HMG group showed significantly higher oestradiol concentrations after stimulation day 5 than either MHP group. The differences in circulating oestradiol concentrations in the MHP-treated patients appeared to be strongly influenced by the mean circulating concentrations of LH in the follicular phase. The patients who showed mean follicular phase LH concentrations of
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a019506