Atrial Natriuretic Factor in Specific Brain Areas of Spontaneously Hypertensive Rats

Atrial natriuretic peptldes (atrial natriuretic factor, ANF) are present in a great number of brain areas inside and outside of the blood-brain barrier. The pattern of distribution implies the involvement of ANF in different physiological functions, such as blood pressure regulation, electrolyte and...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1988-11, Vol.12 (5), p.519-524
Main Authors: BAHNER, UDO, GEIGER, HELMUT, PALKOVITS, MIKLOS, HEIDLAND, AUGUST
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Atrial Natriuretic Factor - analysis
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Brain Chemistry
Cardiology. Vascular system
Experimental diseases
Hypertension - etiology
Male
Medical sciences
Pressoreceptors - physiopathology
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Inbred WKY
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Summary:Atrial natriuretic peptldes (atrial natriuretic factor, ANF) are present in a great number of brain areas inside and outside of the blood-brain barrier. The pattern of distribution implies the involvement of ANF in different physiological functions, such as blood pressure regulation, electrolyte and fluid bomeostasis, and modulation of the neuroendocrine system. To further investigate a possible involvement of central ANF in spontaneous hypertension, we measured levels of ANF in 18 selected, microdissected brain areas of prehypertensive (4-week-old) and hypertensive (12-week-oM) spontaneously hypertensive rats (SHR) and their normotensive control, Wistar-Kyoto rats (WKY), by radioimmunoassay. ANF was significantly decreased in seven brain areas in SHR at both ages investigated; the most pronounced decreases were found in the subfornical organ, in the perifornkal and periventricular hypothalamic nuclei, and in the medial preoptic nucleus. In addition, in young SHR ANF was significantly decreased in the organum vascutosum laminae terminalls and increased in the median eminence. After the development of hypertension, a significant decrease of ANF could be detected in four more brain areas (bed nucleus of the stria terminalis, paraventrkular and arcuate nuclei, dorsal raphe nucleus) of SHR, as compared with normotensive controls, and the increase in the median eminence was no longer detectable. These results suggest a role for ANF in genetk hypertension and the specific importance of certain brain regions.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.12.5.519