Sequence and polymorphism analysis of the murine gene encoding histidyl-tRNA synthetase

The murine histidyl-tRNA synthetase-encoding gene (MMHRS) coding region has been cloned and sequenced. The 1527-bp transcript shows a strikingly similar structural organization to that of its human counterpart, particularly within the three class II aminoacyl-tRNA synthetase structural motifs and th...

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Bibliographic Details
Published in:Gene 1996-10, Vol.178 (1), p.151-156
Main Authors: Blechynden, Lori M., Lawson, Cassandra M., Garlepp, Michael J.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Aminoacyl-tRNA synthetase
Animals
Base Sequence
Cell Line
DNA
Histidine-tRNA Ligase - genetics
Humans
Laboratory mouse
Mice
Molecular Sequence Data
Mus spretus
Nucleotide sequence
Polymorphism, Genetic
Polymyositis
Sequence Homology, Amino Acid
Single-stranded conformational polymorphism
Species Specificity
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Summary:The murine histidyl-tRNA synthetase-encoding gene (MMHRS) coding region has been cloned and sequenced. The 1527-bp transcript shows a strikingly similar structural organization to that of its human counterpart, particularly within the three class II aminoacyl-tRNA synthetase structural motifs and the two histidyl-tRNA synthetase signature regions. It is predicted, as in humans, to have a coiled-coil alpha-helical structure that is characteristic of many autoantigens. MMHRS shows some degree of polymorphism at both the DNA and amino-acid levels, although its sequence is well conserved amongst the commonly used laboratory mouse strains.
ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(96)00358-7