Drosophila melanogaster contains both X-linked and autosomal homologues of the gene encoding calcineurin B

A transcription unit was identified in the 43E polytene band region of the second chromosome of Drosophila melanogaster (Dm) whose putative translation product has 85% amino acid (aa) identity with the B subunit of the calcineurin protein (CnB) from humans. Unlike the previously described intronless...

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Bibliographic Details
Published in:Gene 1996-10, Vol.177 (1), p.149-153
Main Authors: Warren, William D., Phillips, A.Marie, Howells, Antony J.
Format: Article
Language:English
Subjects:
adults
Amino Acid Sequence
amino acid sequences
Animals
autosomes
Base Sequence
Blotting, Northern
Calcineurin
Calcium binding
Calcium-Binding Proteins - genetics
Calmodulin
chromosome mapping
dcnb2 gene
DNA
Drosophila melanogaster
Drosophila melanogaster - genetics
EF hand
genbank/u56245
gene expression
gene location
Genes, Insect
Genetic Linkage
Humans
Intron evolution
introns
messenger RNA
Molecular Sequence Data
nucleic acid hybridization
nucleotide sequences
phosphoprotein phosphatase
polytene chromosomes
Protein phosphatase
pupae
Restriction Mapping
Sequence Homology, Amino Acid
structural genes
X Chromosome
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Summary:A transcription unit was identified in the 43E polytene band region of the second chromosome of Drosophila melanogaster (Dm) whose putative translation product has 85% amino acid (aa) identity with the B subunit of the calcineurin protein (CnB) from humans. Unlike the previously described intronless Dm CnB gene homologue, which is located within the 4F band region of the X chromosome, the coding region of this second CnB is found to be interrupted by three introns. Conceptual translation of both Dm CnB genes predict proteins of identical size that are 98% identical in aa sequence. Northern blot analyses indicate that Dm pupae and adults express two different CnB-encoding transcripts that are differentially regulated.
ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(96)00291-0