Pharmaceutical Applications of Cyclodextrins. 2. In Vivo Drug Delivery

The objective of this Review is to summarize and critique recent findings and applications of both unmodified and modified cyclodextrins for in vivo drug delivery. This review focuses on the use of cyclodextrins for parenteral, oral, ophthalmic, and nasal drug delivery. Other routes including dermal...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1996-11, Vol.85 (11), p.1142-1169
Main Authors: Rajewski, Roger A., Stella, Valentino J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cyclodextrins - administration & dosage
Drug Administration Routes
Drug Carriers
General pharmacology
Humans
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:The objective of this Review is to summarize and critique recent findings and applications of both unmodified and modified cyclodextrins for in vivo drug delivery. This review focuses on the use of cyclodextrins for parenteral, oral, ophthalmic, and nasal drug delivery. Other routes including dermal, rectal, and pulmonary delivery are also briefly addressed. This Review primarily focuses on newer findings concerning cyclodextrin derivatives which are likely to receive regulatory acceptance due to improved aqueous solubility and safety profiles as compared to the unmodified cyclodextrins. Many of the applications reviewed involve the use of hydroxypropyl-β-cyclodextrins (HP-β-CDs) and sulfobutylether-β-cyclodextrins (SBE-β-CDs) which show promise of greater safety while maintaining the ability to form inclusion complexes. The advantages and limitations of HP-β-CD, SBE-β-CD, and other cyclodextrins are addressed.
ISSN:0022-3549
1520-6017
DOI:10.1021/js960075u