Molecular Characterization of a Nonneuronal Human UNC18 Homolog

A cDNA clone encoding a human homolog of theCaenorhabditis elegansunc-18 gene was identified following random sequencing of clones from IL-2-activated human NK cells. This cDNA clone is related to the nonneuronal Munc-18b and so has been called Hunc-18b. The Hunc-18b transcripts were found in most h...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1996-10, Vol.37 (1), p.19-23
Main Authors: Ziegler, Steven F., Mortrud, Martin T., Swartz, Annette R., Baker, Elizabeth, Sutherland, Grant R., Burmeister, Margit, Mulligan, John T.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 19
Cloning, Molecular
DNA, Complementary
Fundamental and applied biological sciences. Psychology
Genes. Genome
Humans
In Situ Hybridization, Fluorescence
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Munc18 Proteins
Nerve Tissue Proteins - genetics
Sequence Homology, Amino Acid
Vesicular Transport Proteins
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Summary:A cDNA clone encoding a human homolog of theCaenorhabditis elegansunc-18 gene was identified following random sequencing of clones from IL-2-activated human NK cells. This cDNA clone is related to the nonneuronal Munc-18b and so has been called Hunc-18b. The Hunc-18b transcripts were found in most human tissues, with the exception of brain and skeletal muscle, and in cells from all lymphoid lineages. The Hunc-18b gene was localized to human chromosome 19p13.2–p13.3, and the mouse homolog, Munc-18b, was mapped to the proximal region of mouse Chromosome 8.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.0515