SPECT with [99mTc]-d,l-Hexamethyl-Propylene Amine Oxime (HM-PAO) Compared with Regional Cerebral Blood Flow Measured by PET: Effects of Linearization

In order to validate the use of technetium-99m–d,l-hexamethylpropyleneamine oxime (HM-PAO) as a flow tracer, a total of 21 cases were studied with single photon emission computerized tomography (SPECT), and compared to regional cerebral blood flow (rCBF) measured by position emission tomography (PET...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 1988-12, Vol.8 (1_suppl), p.S82-S89
Main Authors: Yonekura, Yoshiharu, Nishizawa, Sadahiko, Mukai, Takao, Fujita, Toru, Fukuyama, Hidenao, Ishikawa, Masatsune, Kikuchi, Haruhiko, Konishi, Junji, Andersen, Allan R., Lassen, Niels A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - diagnostic imaging
Cerebrovascular Circulation
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - physiopathology
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Models, Cardiovascular
Nervous system
Organometallic Compounds
Oximes
Radionuclide investigations
Technetium
Technetium Tc 99m Exametazime
Tomography, Emission-Computed - methods
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Summary:In order to validate the use of technetium-99m–d,l-hexamethylpropyleneamine oxime (HM-PAO) as a flow tracer, a total of 21 cases were studied with single photon emission computerized tomography (SPECT), and compared to regional cerebral blood flow (rCBF) measured by position emission tomography (PET) using the oxygen-15 CO2 inhalation technique. Although HM-PAO SPECT and rCBF PET images showed a similar distribution pattern the HM-PAO SPECT image showed less contrast between high and low activity flow regions than the rCBF image and a nonlinear relationship between HM-PAO activity and rCBF was shown. Based on the assumption of flow-dependent backdiffusion of HM-PAO from the brain, we applied a “linearization algorithm” to correct the HM-PAO SPECT images. The corrected HM-PAO SPECT images revealed a good linear correlation with rCBF (r = 0.901, p < 0.001). The results indicated HM-PAO can be used as a flow tracer with SPECT after proper correction.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.1988.36