Resistance patterns of Streptococcus pneumoniae and Haemophilus influenzae isolates recovered in Egypt from children with pneumonia. The Antimicrobial Resistance Surveillance Study Group

Treatment of childhood pneumonia in developing countries requires knowledge of susceptibility patterns for Streptococcus pneumoniae and Haemophilus influenzae. Between October 1991 and April 1993, a surveillance survey of antimicrobial resistance was performed at two fever hospitals in Egypt; nasoph...

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Bibliographic Details
Published in:Clinical infectious diseases 1996-11, Vol.23 (5), p.1069-1074
Main Authors: Ostroff, S M, Harrison, L H, Khallaf, N, Assaad, M T, Guirguis, N I, Harrington, S, el-Alamy, M
Format: Article
Language:English
Subjects:
Ampicillin - pharmacology
Ampicillin Resistance
Child, Preschool
Chloramphenicol - pharmacology
Chloramphenicol Resistance
Egypt
Female
Haemophilus Infections - blood
Haemophilus Infections - microbiology
Haemophilus Infections - pathology
Haemophilus influenzae - drug effects
Haemophilus influenzae - isolation & purification
Humans
Infant
Male
Microbial Sensitivity Tests
Penicillin Resistance
Penicillins - pharmacology
Pneumococcal Infections - blood
Pneumococcal Infections - microbiology
Pneumococcal Infections - pathology
Pneumonia - blood
Pneumonia - microbiology
Pneumonia - pathology
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - isolation & purification
Trimethoprim Resistance
Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
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Summary:Treatment of childhood pneumonia in developing countries requires knowledge of susceptibility patterns for Streptococcus pneumoniae and Haemophilus influenzae. Between October 1991 and April 1993, a surveillance survey of antimicrobial resistance was performed at two fever hospitals in Egypt; nasopharyngeal swab and blood specimens obtained from 1,635 children with pneumonia were cultured for these organisms. Susceptibility testing of these organisms was performed. At least one of these organisms was isolated from nasopharyngeal swab specimens from 73% of the children; 3.7% of blood cultures were positive. For S. pneumoniae strains, 70.9% of nasopharyngeal isolates were calculated to be susceptible to penicillin vs. 77.6% of blood isolates; the percentages of isolates susceptible to co-trimoxazole were 73.0% and 75.0%, respectively. For H. influenzae strains, 93.0% of nasopharyngeal isolates were calculated to be susceptible to ampicillin vs. 100% of blood isolates; the percentages of isolates susceptible to co-trimoxazole were 84.9% and 100%, respectively. Although most S. pneumoniae and H. influenzae strains associated with childhood pneumonia in Cairo were susceptible to penicillins and co-trimoxazole, antimicrobial resistance did not occur.
ISSN:1058-4838