Failure of Combined Chloroquine and High-Dose Primaquine Therapy for Plasmodium vivax Malaria Acquired in Guyana, South America

The presence of chloroquine-resistant Plasmodium vivax malaria in the New World has been suspected but not confirmed. We report the cases of three patients who acquired vivax malaria in Guyana, South America, and for whom standard chloroquine therapy (25 mg/kg) failed despite therapeutic blood level...

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Bibliographic Details
Published in:Clinical infectious diseases 1996-11, Vol.23 (5), p.1171-1173
Main Authors: Phillips, Elizabeth J., Keystone, Jay S., Kain, Kevin C.
Format: Article
Language:English
Subjects:
Adult
Animals
Antimalarials
Blood
Chloroquine - therapeutic use
Directly observed therapy
Drug Therapy, Combination
Fever
Follow-Up Studies
Guyana
Humans
Infections
Malaria
Malaria, Vivax - drug therapy
Male
Medical treatment
Parasites
Plasmodium vivax
Plasmodium vivax - drug effects
Plasmodium vivax - isolation & purification
Primaquine - therapeutic use
Relapse
Treatment Failure
Vivax malaria
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Description
Summary:The presence of chloroquine-resistant Plasmodium vivax malaria in the New World has been suspected but not confirmed. We report the cases of three patients who acquired vivax malaria in Guyana, South America, and for whom standard chloroquine therapy (25 mg/kg) failed despite therapeutic blood levels. The optimal treatment of chloroquine-resistant P. vivax malaria is unknown, but recent studies suggest that a combination of chloroquine (25 mg/kg) and high-dose primaquine (2.5 mg/kg over 48 hours) is effective therapy. Two of our patients had recurrences of P. vivax malaria 6–8 weeks after receiving directly observed therapy with this combination. These cases confirm the presence of chloroquine-resistant P. vivax in Guyana and emphasize the need for better treatment regimens for chloroquine-resistant and primaquine-resistant P. vivax malaria.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/23.5.1171