Plasma 1,5-anhydro- d-glucitol concentration and its relation to other plasma components in renal failure and renal transplant recipients

Plasma levels of 1,5-anhydro- d-glucitol (AG) were measured in non-diabetic patients with renal failure or following renal transplant. For patients with renal failure ( n = 20) from various causes, the plasma level of AG was found to be positively associated with urate and negatively with both urea...

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Bibliographic Details
Published in:Clinica chimica acta 1996-03, Vol.247 (1), p.51-58
Main Authors: Phillipov, George, Ninan, Vadakethu T, Mathew, Timothy H
Format: Article
Language:English
Subjects:
1,5-Anhydro- d-glucitol
Adult
Aged
Blood Chemical Analysis
Creatinine
Deoxyglucose - blood
Female
Humans
Kidney Transplantation - pathology
Male
Middle Aged
Renal failure
Renal Insufficiency - blood
Renal Insufficiency - pathology
Renal transplant
Urate
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Summary:Plasma levels of 1,5-anhydro- d-glucitol (AG) were measured in non-diabetic patients with renal failure or following renal transplant. For patients with renal failure ( n = 20) from various causes, the plasma level of AG was found to be positively associated with urate and negatively with both urea and prior dialysis. The results for seven renal transplant recipients, serially assessed during the post-transplant period, verified an increase in plasma AG with time, approaching normal levels (≥ 70 μmol/1) after 60 days, and which was adversely affected by rejection episodes. The actual mean rate of plasma AG rise ranged from 0.35 to 1.29 μmol/1 per day. AG levels for long term (> 1000 days) surviving renal transplant recipients ( n = 16) were predominantly related to renal function as assessed by plasma creatinine.
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(95)06219-X