Changes in b lymphocyte function in rheumatoid arthritis and lupus nephritis after total lymphoid irradiation

Patients with rheumatoid arthritis and patients with lupus nephritis underwent total lymphoid irradiation (TLI). Peripheral blood mononuclear cells from these patients showed a decrease in pokeweed mitogen—induced immunoglobulin secretion after TLI. A defect in non‐T cells contributed to the decreas...

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Bibliographic Details
Published in:Arthritis and rheumatism 1988-12, Vol.31 (12), p.1481-1491
Main Authors: Solovera, J. J., Fariñas, M. C., Strober, S.
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - therapy
B-Lymphocytes - physiology
Biological and medical sciences
Female
Herpesvirus 4, Human - immunology
Humans
Immunoglobulins - biosynthesis
Immunoglobulins - metabolism
Lupus Nephritis - immunology
Lupus Nephritis - therapy
Lymphatic Irradiation
Lymphocyte Activation
Male
Medical sciences
Monocytes - physiology
Pokeweed Mitogens - pharmacology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Staphylococcus aureus - immunology
T-Lymphocytes - immunology
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Summary:Patients with rheumatoid arthritis and patients with lupus nephritis underwent total lymphoid irradiation (TLI). Peripheral blood mononuclear cells from these patients showed a decrease in pokeweed mitogen—induced immunoglobulin secretion after TLI. A defect in non‐T cells contributed to the decreased response. No defect in the response of non‐T cells to T cell—independent activators of B cells, Staphylococcus aureus Cowan 1 and Epstein‐Barr virus, was observed after TLI. We conclude that TLI induces a selective deficit in B cells, which respond to T cell—dependent mitogen stimulation.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780311204