In vivo Microdialysis of the Hypothalamus: a Suitable Method to Study the Function of Hypophysiotropic Neurons in the Rat

Brain microdialysis is a method commonly exploited by neuropharmacologists to study the mechanism of action and preclinical features of centrally acting drugs. It allows measurement of chemical messengers released into the extracellular space, providing a first approximation of neuronal function in...

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Bibliographic Details
Published in:Journal of neuroendocrinology 1996-01, Vol.8 (1), p.31-33
Main Authors: Cattaneo, Lorena, Müller, Eugenio E., Cocchi, Daniela
Format: Article
Language:English
Subjects:
Animals
corticotrophin releasing hormone
Dialysis - methods
Growth Hormone - physiology
Growth Hormone - secretion
growth hormone autoregulation
Hypothalamus - chemistry
Hypothalamus - physiology
Hypothalamus - secretion
Male
Microchemistry - methods
microdialysis
Neurons, Afferent - chemistry
Neurons, Afferent - physiology
Neurons, Afferent - secretion
Rats
Rats, Sprague-Dawley
Somatostatin - secretion
somatostatin release
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Summary:Brain microdialysis is a method commonly exploited by neuropharmacologists to study the mechanism of action and preclinical features of centrally acting drugs. It allows measurement of chemical messengers released into the extracellular space, providing a first approximation of neuronal function in selected areas. In this study we have applied the microdialysis of the hypothalamus to evaluate the release of somatostatin from neurosecretory neurons which are involved in growth hormone regulation and validated this method with different challenges.
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.1996.tb00683.x