Nondipping of Nocturnal Blood Pressure Is Related to Urinary Albumin Excretion Rate in Patients With Type 2 Diabetes Mellitus

Although cardiovascular and cerebrovascular morbidity and mortality in type 2 diabetic patients is closely related to urinary albumin excretion rate (UAER), the causative mechanisms are not yet identified. The aim of our study was to define the circadian variation of blood pressure (BP) in 72 type 2...

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Bibliographic Details
Published in:American journal of hypertension 1996-11, Vol.9 (11), p.1139-1143
Main Authors: Equiluz-Bruck, S., Schnack, C., Kopp, H.P., Schernthaner, G.
Format: Article
Language:English
Subjects:
Albuminuria - complications
Albuminuria - physiopathology
Biological and medical sciences
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm
circadian variation
diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
drop
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Heart Rate
Humans
hypertension
Hypertension - complications
Hypertension - physiopathology
Male
Medical sciences
microalbuminuria
Middle Aged
nocturnal blood pressure
Urinary albumin excretion
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Summary:Although cardiovascular and cerebrovascular morbidity and mortality in type 2 diabetic patients is closely related to urinary albumin excretion rate (UAER), the causative mechanisms are not yet identified. The aim of our study was to define the circadian variation of blood pressure (BP) in 72 type 2 diabetic patients (mean age 60 years, mean diabetes mellitus duration: 12 years) in comparison with 41 nondiabetic controls with essential hypertension (mean age 58 years) by using ambulatory blood pressure measurement. Thirty diabetic patients had normal UAER (300 mg/24 h). Systolic blood pressure during both nighttime and daytime was significantly elevated in type 2 diabetic patients with macroalbuminuria compared to controls and patients with normal UAER. During nighttime even type 2 diabetic patients with microalbuminuria had significantly elevated systolic blood pressure compared to controls with essential hypertension. We also observed a correlation of nocturnal blood pressure to UAER (systolic: r = 0.32, P < .007 and diastolic: r = 0.24, P < .04). Nondipping (defined as a reduction of nocturnal BP
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/0895-7061(96)00302-0