ICln : A chloride channel paramount for cell volume regulation

Cell volume regulation is a ubiquitous cell regulatory mechanism based on meticulously controlled ion transport mechanisms. Keeping the absolute volume constant seems to be of the highest priority for most cells and is achieved at the expense of altered intracellular ion concentrations. We have been...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 1996-11, Vol.98 (5), p.S98-S101
Main Authors: GSCHWENTNER, M, SUSANNA, A, SCHMARDA, A, LAICH, A, NAGL, U. O, ELLEMUNTER, H, DEETJEN, P, FRICK, J, PAULMICHL, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Size - drug effects
Chloride Channels - pharmacology
Medical sciences
Pharmacology. Drug treatments
Respiratory system
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Summary:Cell volume regulation is a ubiquitous cell regulatory mechanism based on meticulously controlled ion transport mechanisms. Keeping the absolute volume constant seems to be of the highest priority for most cells and is achieved at the expense of altered intracellular ion concentrations. We have been able to demonstrate that ICln, a chloride channel cloned from epithelial cells, is paramount for the ability of swollen cells to regulate their volume back to that under resting conditions. A unique feature of ICln is the distinct sensitivity of these channels for nucleotides and nucleoside analogues added to the extracellular fluid. In addition, cromolyn sodium and nedocromil sodium, drugs used by patients with asthma, are able to impede the function of these channels.
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(96)70023-4