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Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise
Sheri R. Colberg, James M. Hagberg, Steve D. McCole, Joseph M. Zmuda, Paul D. Thompson, and David E. Kelley The Department of Medicine, University of Pittsburgh School of Medicine, and Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261 Received 15 December 1995; accepted i...
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| Published in: | Journal of applied physiology (1985) 1996-11, Vol.81 (5), p.2027-2033 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Colberg, Sheri R Hagberg, James M McCole, Steve D Zmuda, Joseph M Thompson, Paul D Kelley, David E |
| description | Sheri R.
Colberg,
James M.
Hagberg,
Steve D.
McCole,
Joseph M.
Zmuda,
Paul D.
Thompson, and
David E.
Kelley
The Department of Medicine, University of Pittsburgh School of
Medicine, and Department of Veterans Affairs Medical Center,
Pittsburgh, Pennsylvania 15261
Received 15 December 1995; accepted in final form 7 May 1996.
Colberg, Sheri R., James M. Hagberg, Steve D. McCole, Joseph
M. Zmuda, Paul D. Thompson, and David E. Kelley. Utilization of
glycogen but not plasma glucose is reduced in individuals with NIDDM
during mild-intensity exercise. J. Appl.
Physiol. 81(4): 2027-2033, 1996. To test the
hypothesis that substrate utilization during mild-intensity exercise
differs in non-insulin-dependent diabetes mellitus (NIDDM) compared
with nondiabetic subjects, seven lean healthy subjects (L), seven obese
healthy subjects (O), and seven individuals with NIDDM were studied
during 40 min of mild-intensity cycling (40% of peak
O 2 uptake). Systemic utilization of plasma glucose (Glc Rd) was determined by using isotope dilution methods. Gas exchange was measured to determine rates of carbohydrate (CHO) and lipid oxidation. During exercise, when CHO
oxidation was greater than Glc Rd, the net oxidation of glycogen was
calculated as the difference: CHO oxidation Glc Rd. During
mild-intensity cycling, the respiratory exchange ratio was similar
across groups (0.87 ± 0.02, 0.85 ± 0.02, and 0.86 ± 0.01 in
L, O, and NIDDM subjects, respectively), and CHO oxidation accounted
for one-half of total energy expenditure during exercise. Glc Rd
increased during exercise and was greatest in subjects with NIDDM (3.0 ± 0.2, 2.9 ± 0.2, and 4.5 ± 0.4 ml · kg 1 · min 1
in L, O, and NIDDM subjects, respectively,
P |
| doi_str_mv | 10.1152/jappl.1996.81.5.2027 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_proquest_miscellaneous_78566075</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78566075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-135eb5248df099fc04fdd7437739c03fc220f6bd5a24d32f09ab3b4fc21f63653</originalsourceid><addsrcrecordid>eNqFkV-L1TAQxYso63X1GyjkQcSX1iRNmuZRdl1dWPVl9zmk-dObJW1q0rpbP72p93LBBxEGBub8zgzMKYrXCFYIUfzhXk6TrxDnTdWiilYYYvak2GUJl6iB6GmxaxmFJaMte168SOkeQkQIRWfFWctJ5uiuiHez8-6XnF0YQbCg96sKvRlBt8xgDDOYvEyDzPNFhWSASyAavSijgRtzaffT6UX6BB7cvAffri8vvwK9RDf2YHBel26czZjcvALzaKJyybwsntlsMK-O_by4u_p0e_GlvPn--fri402pCIFziWpqOopJqy3k3CpIrNaM1IzVXMHaKoyhbTpNJSa6xhmSXd2RPEe2qRtanxfvDnunGH4sJs1icEkZ7-VowpIEa2nTQPZ_ELUt4ZSzDJIDqGJIKRorpugGGVeBoNgyEX8yEVsmokWCii2TbHtz3L90g9En0zGErL896jIp6W2UY_7TCcOEE8hRxt4fsL3r9w8uGjHt1-SCD_26Hf7rIvk3erV4f2se581zsohJ2_o3m1i4bw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18849597</pqid></control><display><type>article</type><title>Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise</title><source>American Physiological Society Free</source><creator>Colberg, Sheri R ; Hagberg, James M ; McCole, Steve D ; Zmuda, Joseph M ; Thompson, Paul D ; Kelley, David E</creator><creatorcontrib>Colberg, Sheri R ; Hagberg, James M ; McCole, Steve D ; Zmuda, Joseph M ; Thompson, Paul D ; Kelley, David E</creatorcontrib><description>Sheri R.
Colberg,
James M.
Hagberg,
Steve D.
McCole,
Joseph M.
Zmuda,
Paul D.
Thompson, and
David E.
Kelley
The Department of Medicine, University of Pittsburgh School of
Medicine, and Department of Veterans Affairs Medical Center,
Pittsburgh, Pennsylvania 15261
Received 15 December 1995; accepted in final form 7 May 1996.
Colberg, Sheri R., James M. Hagberg, Steve D. McCole, Joseph
M. Zmuda, Paul D. Thompson, and David E. Kelley. Utilization of
glycogen but not plasma glucose is reduced in individuals with NIDDM
during mild-intensity exercise. J. Appl.
Physiol. 81(4): 2027-2033, 1996. To test the
hypothesis that substrate utilization during mild-intensity exercise
differs in non-insulin-dependent diabetes mellitus (NIDDM) compared
with nondiabetic subjects, seven lean healthy subjects (L), seven obese
healthy subjects (O), and seven individuals with NIDDM were studied
during 40 min of mild-intensity cycling (40% of peak
O 2 uptake). Systemic utilization of plasma glucose (Glc Rd) was determined by using isotope dilution methods. Gas exchange was measured to determine rates of carbohydrate (CHO) and lipid oxidation. During exercise, when CHO
oxidation was greater than Glc Rd, the net oxidation of glycogen was
calculated as the difference: CHO oxidation Glc Rd. During
mild-intensity cycling, the respiratory exchange ratio was similar
across groups (0.87 ± 0.02, 0.85 ± 0.02, and 0.86 ± 0.01 in
L, O, and NIDDM subjects, respectively), and CHO oxidation accounted
for one-half of total energy expenditure during exercise. Glc Rd
increased during exercise and was greatest in subjects with NIDDM (3.0 ± 0.2, 2.9 ± 0.2, and 4.5 ± 0.4 ml · kg 1 · min 1
in L, O, and NIDDM subjects, respectively,
P < 0.05), yet Glc Rd was
less than CHO oxidation during exercise, indicating net oxidation of
glycogen. Glycogen oxidation was greater in L and O than in NIDDM
subjects (3.4 ± 1.0, 2.5 ± 0.9, and 1.7 ± 0.8 ml · kg 1 · min 1 ;
P < 0.05). In summary, during
mild-intensity exercise, NIDDM subjects have an increased Glc Rd and a
decreased oxidation of muscle glycogen.
obesity; non-insulin-dependent diabetes mellitus; glucose uptake; muscle glycogen; gas exchange
0161-7567/96 $5.00
Copyright © 1996 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1996.81.5.2027</identifier><identifier>PMID: 8941525</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Anaerobic Threshold - physiology ; Associated diseases and complications ; Biological and medical sciences ; Blood Glucose - metabolism ; Body Composition - physiology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Metabolism - physiology ; Exercise - physiology ; Fatty Acids, Nonesterified - blood ; Female ; Glycogen - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Obesity - metabolism ; Oxidation-Reduction ; Pulmonary Gas Exchange - physiology ; Space life sciences</subject><ispartof>Journal of applied physiology (1985), 1996-11, Vol.81 (5), p.2027-2033</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-135eb5248df099fc04fdd7437739c03fc220f6bd5a24d32f09ab3b4fc21f63653</citedby><cites>FETCH-LOGICAL-c440t-135eb5248df099fc04fdd7437739c03fc220f6bd5a24d32f09ab3b4fc21f63653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2494091$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8941525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colberg, Sheri R</creatorcontrib><creatorcontrib>Hagberg, James M</creatorcontrib><creatorcontrib>McCole, Steve D</creatorcontrib><creatorcontrib>Zmuda, Joseph M</creatorcontrib><creatorcontrib>Thompson, Paul D</creatorcontrib><creatorcontrib>Kelley, David E</creatorcontrib><title>Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Sheri R.
Colberg,
James M.
Hagberg,
Steve D.
McCole,
Joseph M.
Zmuda,
Paul D.
Thompson, and
David E.
Kelley
The Department of Medicine, University of Pittsburgh School of
Medicine, and Department of Veterans Affairs Medical Center,
Pittsburgh, Pennsylvania 15261
Received 15 December 1995; accepted in final form 7 May 1996.
Colberg, Sheri R., James M. Hagberg, Steve D. McCole, Joseph
M. Zmuda, Paul D. Thompson, and David E. Kelley. Utilization of
glycogen but not plasma glucose is reduced in individuals with NIDDM
during mild-intensity exercise. J. Appl.
Physiol. 81(4): 2027-2033, 1996. To test the
hypothesis that substrate utilization during mild-intensity exercise
differs in non-insulin-dependent diabetes mellitus (NIDDM) compared
with nondiabetic subjects, seven lean healthy subjects (L), seven obese
healthy subjects (O), and seven individuals with NIDDM were studied
during 40 min of mild-intensity cycling (40% of peak
O 2 uptake). Systemic utilization of plasma glucose (Glc Rd) was determined by using isotope dilution methods. Gas exchange was measured to determine rates of carbohydrate (CHO) and lipid oxidation. During exercise, when CHO
oxidation was greater than Glc Rd, the net oxidation of glycogen was
calculated as the difference: CHO oxidation Glc Rd. During
mild-intensity cycling, the respiratory exchange ratio was similar
across groups (0.87 ± 0.02, 0.85 ± 0.02, and 0.86 ± 0.01 in
L, O, and NIDDM subjects, respectively), and CHO oxidation accounted
for one-half of total energy expenditure during exercise. Glc Rd
increased during exercise and was greatest in subjects with NIDDM (3.0 ± 0.2, 2.9 ± 0.2, and 4.5 ± 0.4 ml · kg 1 · min 1
in L, O, and NIDDM subjects, respectively,
P < 0.05), yet Glc Rd was
less than CHO oxidation during exercise, indicating net oxidation of
glycogen. Glycogen oxidation was greater in L and O than in NIDDM
subjects (3.4 ± 1.0, 2.5 ± 0.9, and 1.7 ± 0.8 ml · kg 1 · min 1 ;
P < 0.05). In summary, during
mild-intensity exercise, NIDDM subjects have an increased Glc Rd and a
decreased oxidation of muscle glycogen.
obesity; non-insulin-dependent diabetes mellitus; glucose uptake; muscle glycogen; gas exchange
0161-7567/96 $5.00
Copyright © 1996 the American Physiological Society</description><subject>Anaerobic Threshold - physiology</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Composition - physiology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Energy Metabolism - physiology</subject><subject>Exercise - physiology</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Glycogen - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Pulmonary Gas Exchange - physiology</subject><subject>Space life sciences</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkV-L1TAQxYso63X1GyjkQcSX1iRNmuZRdl1dWPVl9zmk-dObJW1q0rpbP72p93LBBxEGBub8zgzMKYrXCFYIUfzhXk6TrxDnTdWiilYYYvak2GUJl6iB6GmxaxmFJaMte168SOkeQkQIRWfFWctJ5uiuiHez8-6XnF0YQbCg96sKvRlBt8xgDDOYvEyDzPNFhWSASyAavSijgRtzaffT6UX6BB7cvAffri8vvwK9RDf2YHBel26czZjcvALzaKJyybwsntlsMK-O_by4u_p0e_GlvPn--fri402pCIFziWpqOopJqy3k3CpIrNaM1IzVXMHaKoyhbTpNJSa6xhmSXd2RPEe2qRtanxfvDnunGH4sJs1icEkZ7-VowpIEa2nTQPZ_ELUt4ZSzDJIDqGJIKRorpugGGVeBoNgyEX8yEVsmokWCii2TbHtz3L90g9En0zGErL896jIp6W2UY_7TCcOEE8hRxt4fsL3r9w8uGjHt1-SCD_26Hf7rIvk3erV4f2se581zsohJ2_o3m1i4bw</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Colberg, Sheri R</creator><creator>Hagberg, James M</creator><creator>McCole, Steve D</creator><creator>Zmuda, Joseph M</creator><creator>Thompson, Paul D</creator><creator>Kelley, David E</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise</title><author>Colberg, Sheri R ; Hagberg, James M ; McCole, Steve D ; Zmuda, Joseph M ; Thompson, Paul D ; Kelley, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-135eb5248df099fc04fdd7437739c03fc220f6bd5a24d32f09ab3b4fc21f63653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Anaerobic Threshold - physiology</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Composition - physiology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Energy Metabolism - physiology</topic><topic>Exercise - physiology</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Glycogen - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Pulmonary Gas Exchange - physiology</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colberg, Sheri R</creatorcontrib><creatorcontrib>Hagberg, James M</creatorcontrib><creatorcontrib>McCole, Steve D</creatorcontrib><creatorcontrib>Zmuda, Joseph M</creatorcontrib><creatorcontrib>Thompson, Paul D</creatorcontrib><creatorcontrib>Kelley, David E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colberg, Sheri R</au><au>Hagberg, James M</au><au>McCole, Steve D</au><au>Zmuda, Joseph M</au><au>Thompson, Paul D</au><au>Kelley, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>81</volume><issue>5</issue><spage>2027</spage><epage>2033</epage><pages>2027-2033</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Sheri R.
Colberg,
James M.
Hagberg,
Steve D.
McCole,
Joseph M.
Zmuda,
Paul D.
Thompson, and
David E.
Kelley
The Department of Medicine, University of Pittsburgh School of
Medicine, and Department of Veterans Affairs Medical Center,
Pittsburgh, Pennsylvania 15261
Received 15 December 1995; accepted in final form 7 May 1996.
Colberg, Sheri R., James M. Hagberg, Steve D. McCole, Joseph
M. Zmuda, Paul D. Thompson, and David E. Kelley. Utilization of
glycogen but not plasma glucose is reduced in individuals with NIDDM
during mild-intensity exercise. J. Appl.
Physiol. 81(4): 2027-2033, 1996. To test the
hypothesis that substrate utilization during mild-intensity exercise
differs in non-insulin-dependent diabetes mellitus (NIDDM) compared
with nondiabetic subjects, seven lean healthy subjects (L), seven obese
healthy subjects (O), and seven individuals with NIDDM were studied
during 40 min of mild-intensity cycling (40% of peak
O 2 uptake). Systemic utilization of plasma glucose (Glc Rd) was determined by using isotope dilution methods. Gas exchange was measured to determine rates of carbohydrate (CHO) and lipid oxidation. During exercise, when CHO
oxidation was greater than Glc Rd, the net oxidation of glycogen was
calculated as the difference: CHO oxidation Glc Rd. During
mild-intensity cycling, the respiratory exchange ratio was similar
across groups (0.87 ± 0.02, 0.85 ± 0.02, and 0.86 ± 0.01 in
L, O, and NIDDM subjects, respectively), and CHO oxidation accounted
for one-half of total energy expenditure during exercise. Glc Rd
increased during exercise and was greatest in subjects with NIDDM (3.0 ± 0.2, 2.9 ± 0.2, and 4.5 ± 0.4 ml · kg 1 · min 1
in L, O, and NIDDM subjects, respectively,
P < 0.05), yet Glc Rd was
less than CHO oxidation during exercise, indicating net oxidation of
glycogen. Glycogen oxidation was greater in L and O than in NIDDM
subjects (3.4 ± 1.0, 2.5 ± 0.9, and 1.7 ± 0.8 ml · kg 1 · min 1 ;
P < 0.05). In summary, during
mild-intensity exercise, NIDDM subjects have an increased Glc Rd and a
decreased oxidation of muscle glycogen.
obesity; non-insulin-dependent diabetes mellitus; glucose uptake; muscle glycogen; gas exchange
0161-7567/96 $5.00
Copyright © 1996 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>8941525</pmid><doi>10.1152/jappl.1996.81.5.2027</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1996-11, Vol.81 (5), p.2027-2033 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78566075 |
| source | American Physiological Society Free |
| subjects | Anaerobic Threshold - physiology Associated diseases and complications Biological and medical sciences Blood Glucose - metabolism Body Composition - physiology Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism - physiology Exercise - physiology Fatty Acids, Nonesterified - blood Female Glycogen - metabolism Humans Male Medical sciences Middle Aged Obesity - metabolism Oxidation-Reduction Pulmonary Gas Exchange - physiology Space life sciences |
| title | Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise |
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