New targets and strategies for the development of antibacterial agents

The increasing incidence of bacterial drug-resistance is stimulating the development of strategies targeting previously unexploited mechanisms of antibiotic action. Combinatorial chemistry, which generates molecularly diverse compounds, target-directed strategies, and high-throughput screens are bei...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 1996-04, Vol.14 (4), p.134-140
Main Author: Desnottes, Jean-François
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacteria - drug effects
Bacterial Adhesion - drug effects
Bacterial Physiological Phenomena
Bacterial Proteins - metabolism
Biological and medical sciences
Biotechnology
Biotechnology - trends
Cell Division - drug effects
Cell Membrane - drug effects
DNA Replication - drug effects
DNA, Bacterial - drug effects
Drug Design
Drug Evaluation, Preclinical
Drug Resistance, Microbial
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Microbiology
Phagocytosis - drug effects
Production of active biomolecules
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Summary:The increasing incidence of bacterial drug-resistance is stimulating the development of strategies targeting previously unexploited mechanisms of antibiotic action. Combinatorial chemistry, which generates molecularly diverse compounds, target-directed strategies, and high-throughput screens are being used to detect potential antibacterial agents. Bacterial DNA replication and cell division are the targets of new screening methods, as are membrane proteins, particularly those constituting efflux pumps; two-component signalling systems are also being targeted. Secondary-screening methods are being developed to find antibiotics that destroy slowly growing or resting bacteria, and to evaluate whether new antibiotics will be active against intracellular bacteria.
ISSN:0167-7799
1879-3096
DOI:10.1016/0167-7799(96)10015-9