Antibody response to Pneumococcal vaccination as related to tonsillectomy

In each of twelve matched pairs of patients undergoing tonsillectomy one patient was vaccinated with Pneumovax®, a pneumococcal polysaccharide antigen, prior to tonsillectomy, the other patient being vaccinated after tonsillectomy. Sera were tested for antibody response to three different pneumococc...

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Bibliographic Details
Published in:Journal of laryngology and otology 1988-10, Vol.102 (10), p.883-885
Main Authors: Stjernquist-Desatnik, A., Prellner, K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies, Viral - biosynthesis
Bacterial Vaccines - administration & dosage
Biological and medical sciences
Child
Child, Preschool
Female
Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics
Humans
Immunoglobulins - biosynthesis
Main Articles
Male
Medical sciences
Pneumococcal Vaccines
Streptococcus pneumoniae - immunology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the upper aerodigestive tract
Tonsillectomy - adverse effects
Vaccination
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Summary:In each of twelve matched pairs of patients undergoing tonsillectomy one patient was vaccinated with Pneumovax®, a pneumococcal polysaccharide antigen, prior to tonsillectomy, the other patient being vaccinated after tonsillectomy. Sera were tested for antibody response to three different pneumococcal types of IgG, IgA andIgM classes. The patients with intact tonsils at vaccination did not develop higher antibody response than did those tonsillectomised prior to vaccination. On the contrary, in the case of pneumococcus type 6A, the IgM antibody response in tonsillectomised patients was significantly higher than that in patients with intact tonsils at vaccination (p = 0.021). Thus, the present study did not support the notion thattonsillectomy affects antibody response against pneumococcal vaccination. The palatine tonsils' role as an immunologically reactive organ is also discussed.
ISSN:0022-2151
1748-5460
DOI:10.1017/S0022215100106723