Simian Immunodeficiency Virus/Delta-Induced Immunodeficiency Disease in Rhesus Monkeys: Relation of Antibody Response and Antigenemia

Infection of the rhesus macaque (Macaca mulatta) with simian immunodeficiency virus (SIV) induces a disease similar to AIDS. We compared SIV-specific antibody and antigenemia with the progression of disease in monkeys experimentally infected with SIV/Delta isolates that varied in pathogenicity. West...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1988-12, Vol.158 (6), p.1277-1286
Main Authors: Zhang, Jing-yu, Martin, Louis N., Watson, Edwin A., Montelaro, Ronald C., West, Melanie, Epstein, Leon, Murpbey-Corb, Micbael
Format: Article
Language:English
Subjects:
AIDS
AIDS/HIV
Analysis of the immune response. Humoral and cellular immunity
Animals
Antibodies
Antibodies, Viral - biosynthesis
Antibody production
Antigens, Viral - analysis
Biological and medical sciences
Blotting, Western
Brain Diseases - immunology
Disease Models, Animal
Disease progression
Encephalitis
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Products, gag
HIV
Immunobiology
Infections
Inoculation
Macaca mulatta
Original Articles
Physiological immunosuppression
Precipitin Tests
Retroviridae Infections - immunology
Retroviridae Proteins - immunology
simian immunodeficiency virus
Simian Immunodeficiency Virus - immunology
Viral diseases
Virion - immunology
Viruses
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Infection of the rhesus macaque (Macaca mulatta) with simian immunodeficiency virus (SIV) induces a disease similar to AIDS. We compared SIV-specific antibody and antigenemia with the progression of disease in monkeys experimentally infected with SIV/Delta isolates that varied in pathogenicity. Western blot, immunoprecipitation, and sandwich enzyme-linked immunosorbent assay of serial sera from macaques infected with attenuated virus revealed a persistent antibody response and no evidence of SIV antigenemia. Immunosuppressed macaques without central nervous system (CNS) infections responded similarly to initial infection, but antibody specific for gag or, less frequently, to gag and env determinants declined predictably before clinical disease. Monkeys with CNS infections, however, had little, if any, detectable antibody to either envelope or gag proteins, regardless of the duration of survival. SIV/Delta-specific antigenemia, evident only in immunodeficient monkeys, fluctuated reciprocally with antibody. Our data suggest that SIV/Delta-induced disease is dependent upon antigenemic episodes that, particularly in animals with CNS infection, appear coincident with diminished antibody.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/158.6.1277