Interleukin-2 Is Indispensable for Development of Immunological Self-Tolerance

Interleukin-2-deficient mice (IL-2−/−) manifest severe immune system abnormalities characterized by an uncontrolled activation and proliferation of lymphocytes. A systemic autoimmune syndrome results, and hemolytic anemia leads to early death especially in mice derived from a BALB/c genotype. Remark...

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Bibliographic Details
Published in:Clinical immunology and immunopathology 1996-12, Vol.81 (3), p.282-286
Main Authors: Klebb, Gabriele, Autenrieth, Ingo B., Haber, Hildegard, Gillert, Esther, Sadlack, Benjamin, Smith, Kendall A., Horak, Ivan
Format: Article
Language:English
Subjects:
Anemia, Hemolytic, Autoimmune - immunology
Anemia, Hemolytic, Autoimmune - prevention & control
Animals
Autoimmunity (experimental aspects and models)
Biological and medical sciences
Crosses, Genetic
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Interleukin-2 - physiology
Interleukin-2 - therapeutic use
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Self Tolerance
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Summary:Interleukin-2-deficient mice (IL-2−/−) manifest severe immune system abnormalities characterized by an uncontrolled activation and proliferation of lymphocytes. A systemic autoimmune syndrome results, and hemolytic anemia leads to early death especially in mice derived from a BALB/c genotype. Remarkably, IL-2 treatment prevents both the activation of the immune system and the development of autoimmune disease. Moreover, adoptive transfer of lymphocytes from IL-2-treated IL-2−/−animals confers protection to IL-2−/−mice, suggesting that IL-2 induces a postnatal differentiation/maturation of regulatory cells necessary for self- and non-self-discrimination.
ISSN:0090-1229
1090-2341
DOI:10.1006/clin.1996.0190