Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go

Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four disti...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-12, Vol.242 (4884), p.1433-1437
Main Authors: VanDongen, A M, Codina, J, Olate, J, Mattera, R, Joho, R, Birnbaumer, L, Brown, A M
Format: Article
Language:English
Subjects:
Adenylyl Imidodiphosphate - pharmacology
Animals
Cattle
Electric Conductivity
GTP-Binding Proteins - pharmacology
Hippocampus - physiology
In Vitro Techniques
Ion channels
Kinetics
Macromolecular Substances
Membrane Potentials - drug effects
Membrane proteins
Neurotransmitter receptors
Potassium Channels - drug effects
Potassium Channels - physiology
Pyramidal Tracts - physiology
Rats
Recombinant Proteins - pharmacology
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Summary:Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.3144040