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Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go
Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four disti...
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| Published in: | Science (American Association for the Advancement of Science) 1988-12, Vol.242 (4884), p.1433-1437 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1437 |
| container_issue | 4884 |
| container_start_page | 1433 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 242 |
| creator | VanDongen, A M Codina, J Olate, J Mattera, R Joho, R Birnbaumer, L Brown, A M |
| description | Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors. |
| doi_str_mv | 10.1126/science.3144040 |
| format | article |
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The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain G0 and recombinant Go alpha. Hence brain Go can couple diverse brain potassium channels to neurotransmitter receptors.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>3144040</pmid><doi>10.1126/science.3144040</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-12, Vol.242 (4884), p.1433-1437 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78573309 |
| source | American Association for the Advancement of Science; Education Collection (Proquest) (PQ_SDU_P3); Social Science Premium Collection (Proquest) (PQ_SDU_P3) |
| subjects | Adenylyl Imidodiphosphate - pharmacology Animals Cattle Electric Conductivity GTP-Binding Proteins - pharmacology Hippocampus - physiology In Vitro Techniques Ion channels Kinetics Macromolecular Substances Membrane Potentials - drug effects Membrane proteins Neurotransmitter receptors Potassium Channels - drug effects Potassium Channels - physiology Pyramidal Tracts - physiology Rats Recombinant Proteins - pharmacology |
| title | Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go |
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