INSULINOTROPIC ACTION OF NOVEL SUCCINIC ACID ESTERS

The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7m M D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and dially...

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Bibliographic Details
Published in:Pharmacological research 1996-04, Vol.33 (4), p.273-275
Main Authors: BJÖRKLING, F., MALAISSE-LAGAE, F., MALAISSE, W.J.
Format: Article
Language:English
Subjects:
Animals
Esters - pharmacology
Insulin - metabolism
insulin release
Insulin Secretion
pancreatic islets
Rats
Succinates - pharmacology
Succinic Acid
succinic acid esters
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Summary:The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7m M D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succinic acid. This indicates that it is possible to design esters of succinic acid which act as insulin secretagogues, while avoiding the undesirable generation of methanol that otherwise results from the use of either the monomethyl or dimethyl ester of this dicarboxylic acid.
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1996.0038