Pharmacokinetics of intravenous captopril in healthy men

The pharmacokinetic characteristics of intravenously-administered captopril were investigated in 7 healthy men 20 to 33 years old. Capropril, labeled with 14C, was given by injection over a 1 min period at mean doses of 2.78 mg (13.8 microCi), 5.67 mg (28.2 microCi) and 11.4 mg (56.8 microCi). Conce...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1988-01, Vol.35 (4), p.367-370
Main Authors: CREASEY, W. A, MORRISON, R. A, SINGHVI, S. M, WILLARD, D. A
Format: Article
Language:English
Subjects:
Adult
Antihypertensive agents
Biological and medical sciences
Captopril - administration & dosage
Captopril - blood
Captopril - pharmacokinetics
Captopril - urine
Cardiovascular system
Half-Life
Humans
Injections, Intravenous
Male
Medical sciences
Metabolic Clearance Rate
Pharmacology. Drug treatments
Time Factors
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Summary:The pharmacokinetic characteristics of intravenously-administered captopril were investigated in 7 healthy men 20 to 33 years old. Capropril, labeled with 14C, was given by injection over a 1 min period at mean doses of 2.78 mg (13.8 microCi), 5.67 mg (28.2 microCi) and 11.4 mg (56.8 microCi). Concentrations of unchanged captopril, captopril disulfide, and other metabolites (collectively) were determined in body fluids. Pharmacokinetic parameters were calculated for unchanged captopril, and it was shown that the disposition of intravenously-administered drug was linear with respect to dose over the dosage range studied.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00561366