Identification of an amphotericin B resistant strain of Candida albicans using a rapid 3H-glucose incorporation microassay

Using a 3H-glucose incorporation assay, antifungal sensitivity testing undertaken on an isolate of Candida albicans cultured from the blood of a bone marrow transplant patient documented resistance to amphotericin B but sensitivity to fluconazole and itraconazole. Information obtained from in vitro...

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Bibliographic Details
Published in:The Journal of infection 1996-11, Vol.33 (3), p.221-226
Main Authors: Sweeney, J.F., Greene, J.N., Hiemenz, J.W., Wei, S., Rosemurgy, A.S., Djeu, J.Y.
Format: Article
Language:English
Subjects:
Adult
Amphotericin B - pharmacology
Antifungal Agents - pharmacology
Biological and medical sciences
Candida albicans - drug effects
Candida albicans - isolation & purification
Candidiasis - drug therapy
Candidiasis - microbiology
Drug Resistance, Microbial
Female
Fluconazole - pharmacology
Human mycoses
Humans
Immunocompromised Host
Infectious diseases
Itraconazole - pharmacology
Medical sciences
Microbial Sensitivity Tests
Mycoses
Mycotic sepsis
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Summary:Using a 3H-glucose incorporation assay, antifungal sensitivity testing undertaken on an isolate of Candida albicans cultured from the blood of a bone marrow transplant patient documented resistance to amphotericin B but sensitivity to fluconazole and itraconazole. Information obtained from in vitro antifungal sensitivity testing can be used to direct in vivo antifungal therapy. Widespread application of standardized in vitro antifungal sensitivity testing is needed.
ISSN:0163-4453
1532-2742
DOI:10.1016/S0163-4453(96)92369-5