Six Lignans from Phyllanthus myrtifolius

Six lignans comprising phyllamyricins D (1), E (2), and F (3) and phyllamyricosides A (4), B (5), and C (6) were isolated in a continuing study of Phyllanthus myrtifolius. Compounds 1 and 2 are 2a-methoxy-4-aryl-2,3-naphthalides. Compounds 3−6 belong to the 4-arylnaphthalene class, with compounds 4−...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1996-11, Vol.59 (11), p.1061-1065
Main Authors: Lee, Shoei-Sheng, Lin, Mei-Tsu, Liu, Chao-Lin, Lin, Yung-Yaw, Liu, Karin C. S. Chen
Format: Article
Language:English
Subjects:
ACTIVADOR ENZIMATICO
ACTIVATEUR D'ENZYME
AIDS/HIV
Biological and medical sciences
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DRUG PLANTS
ENZYME ACTIVATORS
ESPECTROMETRIA
ESTRUCTURA QUIMICA
General pharmacology
GENERO HUMANO
GENRE HUMAIN
HERPETOVIRIDAE
HIV Reverse Transcriptase - antagonists & inhibitors
HUMAN IMMUNODEFICIENCY VIRUS
human immunodeficiency virus 1
Humans
Lignans - isolation & purification
Lignans - pharmacology
LIGNINAS
LIGNINE
LIGNINS
Magnetic Resonance Spectroscopy
MANKIND
Medical sciences
Naphthalenes - isolation & purification
Naphthalenes - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PHYLLAMYRICINS
PHYLLAMYRICOSIDES
PHYLLANTHUS
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
REVERSE TRANSCRIPTASE
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
STRUCTURE CHIMIQUE
TRANSCRIPTASA INVERSA
TRANSCRIPTASE INVERSE
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Summary:Six lignans comprising phyllamyricins D (1), E (2), and F (3) and phyllamyricosides A (4), B (5), and C (6) were isolated in a continuing study of Phyllanthus myrtifolius. Compounds 1 and 2 are 2a-methoxy-4-aryl-2,3-naphthalides. Compounds 3−6 belong to the 4-arylnaphthalene class, with compounds 4−6 being O-β-glucosides. Their structures were elucidated on the basis of spectral analysis. Compound 4 increased the activity of HIV-1 reverse transcriptase by 65% at a concentration of 1.89 μM.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960322+