Adenosine-induced renal vasoconstriction in man

The aim of the study was to evaluate the effects of adenosine on renal blood flow in humans. Eleven normotensive patients (mean age 53 +/- 11 years) with normal renal angiograms were enrolled in the study. Arterial blood pressure, one ECG lead and arterial renal blood flow velocity, by intravascular...

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Bibliographic Details
Published in:Cardiovascular research 1996-11, Vol.32 (5), p.949-953
Main Authors: MARRACCINI, P, FEDELE, S, MARZILLI, M, ORSINI, E, DUKIC, G, SERASINI, L, L'ABBATE, A
Format: Article
Language:English
Subjects:
Adenosine - pharmacology
Biological and medical sciences
Blood vessels and receptors
Female
Fundamental and applied biological sciences. Psychology
Humans
Kidney - diagnostic imaging
Male
Middle Aged
Radiography
Renal Circulation - drug effects
Vasodilator Agents - pharmacology
Vertebrates: cardiovascular system
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Summary:The aim of the study was to evaluate the effects of adenosine on renal blood flow in humans. Eleven normotensive patients (mean age 53 +/- 11 years) with normal renal angiograms were enrolled in the study. Arterial blood pressure, one ECG lead and arterial renal blood flow velocity, by intravascular Doppler catheter, were monitored throughout the procedure. Incremental doses (10(-5), 10(-4), 10(-3), 2 x 10(-3), 5 x 10(-3), 10(-2), 10(-1), 1 mg) were selectively injected, at 5-min intervals, in a renal artery. Adenosine administration had no significant effects on blood pressure, heart rate and atrio-ventricular conduction. A progressive reduction in renal blood flow velocity (from 16.36 +/- 1.9 to 3.9 +/- 0.8 cm/s, P < 0.0001) was observed. Following adenosine the decrease of flow velocity was immediate and its duration was proportional to dosage (from 0.5 +/- 0.4 s at 10(-5) mg to 31 +/- 6.5 s at 1 mg). Renal angiography, repeated in four patients during flow velocity decrement, showed no changes in vessel diameter. Exogenous adenosine-induced a marked and transient reduction in renal blood flow in man. This effect suggests that adenosine or its metabolites may be directly implicated in rapid and powerful mechanisms of cardiac output redistribution. Thus endogenous adenosine could have a role in regulating renal blood flow in physiological and pathological situations like strenuous exercise, hemorrhage shock and cardiac failure.
ISSN:0008-6363
1755-3245
DOI:10.1016/0008-6363(96)00128-9