Identification of the human hepatic microsomal glucose-6-phosphatase enzyme

The glucose-6-phosphatase enzyme protein of the human hepatic microsomal glucose-6-phosphatase system was identified as a 36.5 kDa polypeptide. The 36.5 kDa glucose-6-phosphatase enzyme protein was shown to be absent in the microsomes isolated from a patient previously diagnosed as having a type 1a...

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Bibliographic Details
Published in:FEBS letters 1988-12, Vol.242 (1), p.153-156
Main Authors: Burchell, Ann, Waddell, Ian D., Countaway, Janice L., Arion, William J., Hume, Robert
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Electrophoresis, Polyacrylamide Gel
Glucose-6-phosphatase
Glucose-6-Phosphatase - metabolism
Glucose-6-Phosphate
Glucosephosphates - metabolism
Glycogen storage disease
Glycogen Storage Disease Type I - enzymology
Humans
Immunoblotting
liver
Liver microsome
Microsomes, Liver - enzymology
Phosphohydrolase
Phosphorus Radioisotopes
Rats
Rats, Inbred Strains
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Summary:The glucose-6-phosphatase enzyme protein of the human hepatic microsomal glucose-6-phosphatase system was identified as a 36.5 kDa polypeptide. The 36.5 kDa glucose-6-phosphatase enzyme protein was shown to be absent in the microsomes isolated from a patient previously diagnosed as having a type 1a glycogen storage disease.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)81005-6