Clinical features, frequency and prognosis of Dukes' A colorectal carcinoma: A population-based investigation

The main aim of this study was, through the data of a population-based Registry, to establish the incidence of Dukes' A lesions by year of registration and the main clinical features, and to assess cancer-specific survival. One hundred and eighteen Dukes' A colorectal tumours were diagnose...

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Bibliographic Details
Published in:European journal of cancer (1990) 1996-10, Vol.32 (11), p.1957-1962
Main Authors: Di Gregorio, C., Fante, R., Roncucci, L., Tamassia, M.G., Losi, L., Benatti, P., Pedroni, M., Percesepe, A., De Pietri, S., de Leon, M.Ponz
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Colonic Neoplasms - epidemiology
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
colorectal carcinoma
Dukes' stage
Endoscopy
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Incidence
Italy - epidemiology
Male
Medical sciences
Middle Aged
Neoplasm Staging
population-based
Prognosis
Prospective Studies
Rectal Neoplasms - epidemiology
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
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Summary:The main aim of this study was, through the data of a population-based Registry, to establish the incidence of Dukes' A lesions by year of registration and the main clinical features, and to assess cancer-specific survival. One hundred and eighteen Dukes' A colorectal tumours were diagnosed (in 117 patients) out of 1337 registered between 1984 and 1992 in the Health Care District of Modena, Northern Italy; 94 patients were treated with surgery and 23 with endoscopie polypectomy. The frequency of Dukes' A tumours ranged between 4.8% and 18% by year of registration. Dukes' A carcinomas were significantly more frequent in the distal colon. Only 5 patients (4%) died of their cancer, and in all patients the tumour was localised in the rectum. Carcinomas associated with a poor prognosis did not show any of the biological variables usually associated with an unfavourable outcome, but, our data suggest the possibility of incomplete removal of tumours at surgery.
ISSN:0959-8049
1879-0852
DOI:10.1016/0959-8049(96)00246-8