Voltammetric determination of imipramine hydrochloride and amitriptyline hydrochloride using a polymer-modified carbon paste electrode

In this paper the voltammetric behaviors of imipramine·HCl and amitriptyline·HCl, which are both tricyclic antidepressants, were investigated using a carbon paste electrode, modified by the addition of poly( N-vinylimidazole), in various solutions of different pHs. It was shown that the current dens...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1996-12, Vol.15 (3), p.371-381
Main Authors: Biryol, İnci, Uslu, Bengi, Küçükyavuz, Zuhal
Format: Article
Language:English
Subjects:
Amitriptyline
Amitriptyline - analysis
Amitriptyline - chemistry
Analysis
Antidepressive Agents, Tricyclic - analysis
Antidepressive Agents, Tricyclic - chemistry
Biological and medical sciences
Carbon - chemistry
Chemistry, Pharmaceutical - methods
Electrochemistry
Electrons
General pharmacology
Imipramine
Imipramine - analysis
Imipramine - chemistry
Medical sciences
Pharmacology. Drug treatments
Polymer-modified carbon paste electrode
Polymers - chemistry
Voltammetry
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Summary:In this paper the voltammetric behaviors of imipramine·HCl and amitriptyline·HCl, which are both tricyclic antidepressants, were investigated using a carbon paste electrode, modified by the addition of poly( N-vinylimidazole), in various solutions of different pHs. It was shown that the current density for imipramine increased with modification of the carbon paste electrode and amitriptyline, which was electroinactive with the normal carbon paste electrode, became electroactive on the modified electrode. The optimum conditions for the quantitive determination of imipramine·HCl and amitriptyline·HCl were determined and statistical analysis of the linear relationship between current and concentration is given. The method was applied for the determination of these substances in the pharmaceutical dosage forms.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(96)01866-3