Biomedical Applications of Polyurethanes: Implications of Failure Mechanisms

Three mechanisms have been described which explain various observed interactions between polyurethane chemistry and body chemistry. These include calcification, environmental stress cracking, and chain scission. Each may result in implant device failure, and each appears to involve metal ion complex...

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Bibliographic Details
Published in:Journal of biomaterials applications 1988, Vol.3 (2), p.207-227
Main Authors: Phillips, R.E., Smith, M.C., Thoma, R.J.
Format: Article
Language:English
Subjects:
Biocompatible Materials - analysis
Biological and medical sciences
Calcinosis - etiology
Equipment and Supplies
Equipment Failure
Humans
Ions
Materials Testing - methods
Medical sciences
Models, Molecular
Polyurethanes - analysis
Prostheses and Implants
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Technology. Biomaterials. Equipments. Material. Instrumentation
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Summary:Three mechanisms have been described which explain various observed interactions between polyurethane chemistry and body chemistry. These include calcification, environmental stress cracking, and chain scission. Each may result in implant device failure, and each appears to involve metal ion complexation as a key parameter. Continued expansion of polyurethane into implantable product applications will require further clarification of the effect of each of these interactions on long-term product performance. It is believed that design considerations and polymer modifications will help control the effects of each of the interactions and will result in new and improved polyurethane implant products.
ISSN:0885-3282
1530-8022
DOI:10.1177/088532828800300204