Intraaccumbens administration of NMDA receptor antagonist (±)-CPP prevents locomotor activation conditioned by morphine and amphetamine in rats

In the present experiments the influence of NMDA receptor antagonist (±)-CPP on morphine- and amphetamine-conditioned activation of locomotor activity was studied in rats chronically implanted with bilateral cannulas in the nucleus accumbens septi. Animals were conditioned by pairing subcutaneous in...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1996-10, Vol.55 (2), p.203-207
Main Authors: Bespalov, Anton Yu, Zvartau, Edwin E.
Format: Article
Language:English
Subjects:
Amphetamine
Amphetamine - antagonists & inhibitors
Amphetamine - pharmacology
Analgesics, Opioid - antagonists & inhibitors
Analgesics, Opioid - pharmacology
Animals
Central Nervous System Stimulants - antagonists & inhibitors
Central Nervous System Stimulants - pharmacology
Conditioning
Conditioning (Psychology) - drug effects
Excitatory Amino Acid Antagonists - administration & dosage
Excitatory Amino Acid Antagonists - pharmacology
Injections
Locomotor activity
Male
Morphine
Morphine - antagonists & inhibitors
Morphine - pharmacology
Motor Activity - drug effects
NMDA receptor antagonist
Nucleus accumbens
Nucleus Accumbens - anatomy & histology
Nucleus Accumbens - physiology
Piperazines - administration & dosage
Piperazines - pharmacology
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
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Summary:In the present experiments the influence of NMDA receptor antagonist (±)-CPP on morphine- and amphetamine-conditioned activation of locomotor activity was studied in rats chronically implanted with bilateral cannulas in the nucleus accumbens septi. Animals were conditioned by pairing subcutaneous injections of morphine (3.0 mg/kg), amphetamine (1.5 mg/kg), or saline with a distinctive environment. Following the five drug-environment pairings, rats displayed significant increase in locomotion when exposed to the drug-paired environment. The expression of this conditioned response was completely prevented by the bilateral intraaccumbens pretreatment with (±)-CPP (1.0, but not 0.1 or 0.3 μg/ μl/side). These findings suggest that the locomotor hyperactivity conditioned by morphine and amphetamine involves the activation of NMDA receptors within the nucleus accumbens.
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(96)00065-2