Liquid chromatographic-thermospray tandem mass spectrometric quantitative analysis of some drugs with hypnotic. sedative and tranquillising properties in whole blood

Results are presented of a liquid chromatographic-thermospray tandem mass spectrometric method of analysing different drugs in whole blood. Substances with hypnotic, sedative and tranquillising properties from the benzodiazepine, the thioxanthene, the butyrophenone, the methadone and the diphenylbut...

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Published in:Journal of chromatography. B, Biomedical applications Biomedical applications, 1996-11, Vol.686 (1), p.27-34
Main Authors: Verweij, Anthonie M.A., Hordijk, Maarten L., Lipman, Peter J.L.
Format: Article
Language:English
Subjects:
Benzodiazepines
Benzodiazepines - blood
Butyrophenones
Butyrophenones - blood
Calibration
Chromatography, High Pressure Liquid - methods
Diphenylbutylpiperidines
Humans
Mass Spectrometry - methods
Methadone - blood
Methadones
Narcotics - blood
Piperidines - blood
Sensitivity and Specificity
Thioxanthenes
Thioxanthenes - blood
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description Results are presented of a liquid chromatographic-thermospray tandem mass spectrometric method of analysing different drugs in whole blood. Substances with hypnotic, sedative and tranquillising properties from the benzodiazepine, the thioxanthene, the butyrophenone, the methadone and the diphenylbutylpiperidine groups were investigated. It appears that ten to hundred times lower detection limits for the substances in whole blood can be reached with this method compared with methods more commonly used. Detection limits in the range 10–100 pg per injection (equivalent to 0.05-0.5 ng/ml whole blood) were reached for the majority of the compounds.
doi_str_mv 10.1016/S0378-4347(96)00035-7
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identifier ISSN: 0378-4347
ispartof Journal of chromatography. B, Biomedical applications, 1996-11, Vol.686 (1), p.27-34
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source ScienceDirect Freedom Collection 2022-2024
subjects Benzodiazepines
Benzodiazepines - blood
Butyrophenones
Butyrophenones - blood
Calibration
Chromatography, High Pressure Liquid - methods
Diphenylbutylpiperidines
Humans
Mass Spectrometry - methods
Methadone - blood
Methadones
Narcotics - blood
Piperidines - blood
Sensitivity and Specificity
Thioxanthenes
Thioxanthenes - blood
title Liquid chromatographic-thermospray tandem mass spectrometric quantitative analysis of some drugs with hypnotic. sedative and tranquillising properties in whole blood
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