An Unusual Subacute Progressive Motor Neuronopathy with Myasthenia-like Features

The initial presentation and clinical course of this 60-year old woman suggested a diagnosis of myasthenia gravis. The subsequent development of tongue fasciculations and the lack of response to treatment made a diagnosis of amyotrophic lateral sclerosis (ALS) more likely despite the presence of con...

Full description

Saved in:
Bibliographic Details
Published in:Canadian journal of neurological sciences 1988-08, Vol.15 (3), p.304-309
Main Authors: Noseworthy, J.H., Rae-Grant, A.D., Brown, W.F.
Format: Article
Language:English
Subjects:
Amyotrophic Lateral Sclerosis - diagnosis
Amyotrophic Lateral Sclerosis - pathology
Amyotrophic Lateral Sclerosis - physiopathology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnosis, Differential
Electric Stimulation
Female
Humans
Medical sciences
Middle Aged
Myasthenia Gravis - diagnosis
Myasthenia Gravis - pathology
Myasthenia Gravis - physiopathology
Neurology
Original Articles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The initial presentation and clinical course of this 60-year old woman suggested a diagnosis of myasthenia gravis. The subsequent development of tongue fasciculations and the lack of response to treatment made a diagnosis of amyotrophic lateral sclerosis (ALS) more likely despite the presence of conjugate gaze paresis and the absence of many of the typical clinical and electromyographic (EMG) findings seen in this condition. The pathological findings were consistent with either a motor neuronopathy or an unusual variant of ALS. We review the clinical and pathological features of this unusual case in this report.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100027797