On the distribution of cholecystokinin B receptors in monkey brain

In view of recent evidence for a role for the B subtype of cholecystokinin (CCK B) receptor in panic and anxiety, the distribution of CCK B receptors in the forebrain of a Rhesus macaca monkey was examined by receptor autoradiography employing [ 125I] d-Tyr 25(Nleu 28,31)-CCK25-33S. CCK B receptors...

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Bibliographic Details
Published in:Brain research 1996-11, Vol.738 (2), p.313-318
Main Authors: Mercer, L.D., Beart, P.M., Horne, M.K., Finkelstein, D.I., Carrive, P., Paxinos, G.
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Brain Chemistry - physiology
Cholecystokinin
Corpus Striatum - chemistry
Cortex
Diencephalon - chemistry
Female
Frontal Lobe - chemistry
Hippocampus - chemistry
Macaca mulatta
Mesencephalon - chemistry
Monkey
Neuroanatomy
Receptor subtype
Receptor, Cholecystokinin B
Receptors, Cholecystokinin - analysis
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Summary:In view of recent evidence for a role for the B subtype of cholecystokinin (CCK B) receptor in panic and anxiety, the distribution of CCK B receptors in the forebrain of a Rhesus macaca monkey was examined by receptor autoradiography employing [ 125I] d-Tyr 25(Nleu 28,31)-CCK25-33S. CCK B receptors were widely and topographically distributed in cortex. Other structures with notable labelling included the basal ganglia, presubiculum, amygdala, mamillary bodies, cerebellar cortex and pineal gland. The distribution of CCK B receptors further supports roles for this peptide in behavioural processes.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(96)00477-5