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Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders
Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD, n = 12), Parkinson's disease (PD, n = 14), Hunti...
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| Published in: | Brain research 1996-11, Vol.738 (2), p.265-274 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c509t-791100eaa2fc65d70ba5a3be6010fff4c52eabe2f22897748c59a9a25a9c52f03 |
| container_end_page | 274 |
| container_issue | 2 |
| container_start_page | 265 |
| container_title | Brain research |
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| creator | Loeffler, D.A. LeWitt, P.A. Juneau, P.L. Sima, A.A.F. Nguyen, H.-U. DeMaggio, A.J. Brickman, C.M. Brewer, G.J. Dick, R.D. Troyer, M.D. Kanaley, L. |
| description | Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD,
n = 12), Parkinson's disease (PD,
n = 14), Huntington's disease (HD,
n = 11), progressive supranuclear palsy (PSP,
n = 11), young adult normal controls (YC,
n = 6) and elderly normal controls (EC,
n = 7). Mean CP concentrations were significantly increased vs. EC (
P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen, PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. lmmunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress. |
| doi_str_mv | 10.1016/S0006-8993(96)00782-2 |
| format | article |
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n = 12), Parkinson's disease (PD,
n = 14), Huntington's disease (HD,
n = 11), progressive supranuclear palsy (PSP,
n = 11), young adult normal controls (YC,
n = 6) and elderly normal controls (EC,
n = 7). Mean CP concentrations were significantly increased vs. EC (
P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen, PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. lmmunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(96)00782-2</identifier><identifier>PMID: 8955522</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute phase protein ; Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Brain - metabolism ; Brain - pathology ; Brain - physiology ; Case-Control Studies ; Cell Count ; Ceruloplasmin ; Ceruloplasmin - metabolism ; Copper ; Copper - metabolism ; Hippocampus - pathology ; Humans ; Huntington Disease - metabolism ; Huntington Disease - pathology ; Huntington Disease - physiopathology ; Huntington's disease ; Middle Aged ; Nerve Degeneration - physiology ; Neurons - pathology ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Progressive supranuclear palsy ; Supranuclear Palsy, Progressive - metabolism ; Supranuclear Palsy, Progressive - pathology ; Supranuclear Palsy, Progressive - physiopathology</subject><ispartof>Brain research, 1996-11, Vol.738 (2), p.265-274</ispartof><rights>1996 Elsevier Science B.V. All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-791100eaa2fc65d70ba5a3be6010fff4c52eabe2f22897748c59a9a25a9c52f03</citedby><cites>FETCH-LOGICAL-c509t-791100eaa2fc65d70ba5a3be6010fff4c52eabe2f22897748c59a9a25a9c52f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8955522$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Loeffler, D.A.</creatorcontrib><creatorcontrib>LeWitt, P.A.</creatorcontrib><creatorcontrib>Juneau, P.L.</creatorcontrib><creatorcontrib>Sima, A.A.F.</creatorcontrib><creatorcontrib>Nguyen, H.-U.</creatorcontrib><creatorcontrib>DeMaggio, A.J.</creatorcontrib><creatorcontrib>Brickman, C.M.</creatorcontrib><creatorcontrib>Brewer, G.J.</creatorcontrib><creatorcontrib>Dick, R.D.</creatorcontrib><creatorcontrib>Troyer, M.D.</creatorcontrib><creatorcontrib>Kanaley, L.</creatorcontrib><title>Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD,
n = 12), Parkinson's disease (PD,
n = 14), Huntington's disease (HD,
n = 11), progressive supranuclear palsy (PSP,
n = 11), young adult normal controls (YC,
n = 6) and elderly normal controls (EC,
n = 7). Mean CP concentrations were significantly increased vs. EC (
P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen, PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. lmmunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress.</description><subject>Acute phase protein</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - physiology</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Ceruloplasmin</subject><subject>Ceruloplasmin - metabolism</subject><subject>Copper</subject><subject>Copper - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Huntington Disease - metabolism</subject><subject>Huntington Disease - pathology</subject><subject>Huntington Disease - physiopathology</subject><subject>Huntington's disease</subject><subject>Middle Aged</subject><subject>Nerve Degeneration - physiology</subject><subject>Neurons - pathology</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Progressive supranuclear palsy</subject><subject>Supranuclear Palsy, Progressive - metabolism</subject><subject>Supranuclear Palsy, Progressive - pathology</subject><subject>Supranuclear Palsy, Progressive - physiopathology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkF1LwzAUhoMoOj9-wqBXohfVk3RJmyuR4cdg4IWKlyFNTyTSNjNpB_57Mzd2KwRC8j7nvPAQMqVwQ4GK21cAEHklZXElxTVAWbGcHZAJrUqWCzaDQzLZIyfkNMav9CwKCcfkuJKcc8Ym5GPRm4A6YpMF_HS-121WB-36zPjeYD8EPaTfmHmbGQxj61etjl3K0-lxDL7BT-xxg60xa1z0ocEQz8mR1W3Ei919Rt4fH97mz_ny5Wkxv1_mhoMc8lJSCoBaM2sEb0qoNddFjQIoWGtnhjPUNTLLWCXLclYZLrXUjGuZIgvFGbnc7l0F_z1iHFTnosG21T36MaqyEpA6xL8g5aWgjBUJ5FvQBB9jQKtWwXU6_CgKamNe_ZlXG61KCvVnXrE0N90VjHWHzX5qpzrld9sck461w6CicZgcNy6gGVTj3T8Nv57-lLk</recordid><startdate>19961104</startdate><enddate>19961104</enddate><creator>Loeffler, D.A.</creator><creator>LeWitt, P.A.</creator><creator>Juneau, P.L.</creator><creator>Sima, A.A.F.</creator><creator>Nguyen, H.-U.</creator><creator>DeMaggio, A.J.</creator><creator>Brickman, C.M.</creator><creator>Brewer, G.J.</creator><creator>Dick, R.D.</creator><creator>Troyer, M.D.</creator><creator>Kanaley, L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19961104</creationdate><title>Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders</title><author>Loeffler, D.A. ; LeWitt, P.A. ; Juneau, P.L. ; Sima, A.A.F. ; Nguyen, H.-U. ; DeMaggio, A.J. ; Brickman, C.M. ; Brewer, G.J. ; Dick, R.D. ; Troyer, M.D. ; Kanaley, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-791100eaa2fc65d70ba5a3be6010fff4c52eabe2f22897748c59a9a25a9c52f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acute phase protein</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain - physiology</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Ceruloplasmin</topic><topic>Ceruloplasmin - metabolism</topic><topic>Copper</topic><topic>Copper - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Huntington Disease - metabolism</topic><topic>Huntington Disease - pathology</topic><topic>Huntington Disease - physiopathology</topic><topic>Huntington's disease</topic><topic>Middle Aged</topic><topic>Nerve Degeneration - physiology</topic><topic>Neurons - pathology</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Progressive supranuclear palsy</topic><topic>Supranuclear Palsy, Progressive - metabolism</topic><topic>Supranuclear Palsy, Progressive - pathology</topic><topic>Supranuclear Palsy, Progressive - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Loeffler, D.A.</creatorcontrib><creatorcontrib>LeWitt, P.A.</creatorcontrib><creatorcontrib>Juneau, P.L.</creatorcontrib><creatorcontrib>Sima, A.A.F.</creatorcontrib><creatorcontrib>Nguyen, H.-U.</creatorcontrib><creatorcontrib>DeMaggio, A.J.</creatorcontrib><creatorcontrib>Brickman, C.M.</creatorcontrib><creatorcontrib>Brewer, G.J.</creatorcontrib><creatorcontrib>Dick, R.D.</creatorcontrib><creatorcontrib>Troyer, M.D.</creatorcontrib><creatorcontrib>Kanaley, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loeffler, D.A.</au><au>LeWitt, P.A.</au><au>Juneau, P.L.</au><au>Sima, A.A.F.</au><au>Nguyen, H.-U.</au><au>DeMaggio, A.J.</au><au>Brickman, C.M.</au><au>Brewer, G.J.</au><au>Dick, R.D.</au><au>Troyer, M.D.</au><au>Kanaley, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1996-11-04</date><risdate>1996</risdate><volume>738</volume><issue>2</issue><spage>265</spage><epage>274</epage><pages>265-274</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD,
n = 12), Parkinson's disease (PD,
n = 14), Huntington's disease (HD,
n = 11), progressive supranuclear palsy (PSP,
n = 11), young adult normal controls (YC,
n = 6) and elderly normal controls (EC,
n = 7). Mean CP concentrations were significantly increased vs. EC (
P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen, PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. lmmunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8955522</pmid><doi>10.1016/S0006-8993(96)00782-2</doi><tpages>10</tpages></addata></record> |
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| ispartof | Brain research, 1996-11, Vol.738 (2), p.265-274 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Acute phase protein Adult Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Brain - metabolism Brain - pathology Brain - physiology Case-Control Studies Cell Count Ceruloplasmin Ceruloplasmin - metabolism Copper Copper - metabolism Hippocampus - pathology Humans Huntington Disease - metabolism Huntington Disease - pathology Huntington Disease - physiopathology Huntington's disease Middle Aged Nerve Degeneration - physiology Neurons - pathology Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Progressive supranuclear palsy Supranuclear Palsy, Progressive - metabolism Supranuclear Palsy, Progressive - pathology Supranuclear Palsy, Progressive - physiopathology |
| title | Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders |
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