Antimicrobial and immunological activity of ethanol extracts and fractions from Isopyrum thalictroides

The antimicrobial and immunological properties of ethanol extracts, non-alkaloid, tertiary alkaloid and quaternary alkaloid fractions, obtained from roots and aerial parts of Isopyrum thalictroides were examined. The non-alkaloid fraction from aerial parts inhibited the growth of seven test microorg...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1996-11, Vol.54 (2), p.143-151
Main Authors: Ivanovska, N., Philipov, S., Istatkova, R., Georgieva, P.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Animals
Anti-Infective Agents - pharmacology
Anti-Inflammatory Agents - pharmacology
Antibody Formation - drug effects
Antimicrobial activity
Biological and medical sciences
Complement Pathway, Classical - drug effects
Erythrocytes - drug effects
Erythrocytes - immunology
Ethanol - chemistry
Fractions
General pharmacology
Immunological activity
Isopyrum thalictroides
Lymphocyte Activation - drug effects
Male
Medical sciences
medicinal plants
Mice
Mice, Inbred ICR
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Sheep
traditional medicine
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Summary:The antimicrobial and immunological properties of ethanol extracts, non-alkaloid, tertiary alkaloid and quaternary alkaloid fractions, obtained from roots and aerial parts of Isopyrum thalictroides were examined. The non-alkaloid fraction from aerial parts inhibited the growth of seven test microorganisms and was the most effective suppresser of classical pathway (CP) complement activity in normal human serum (NHS) and guinea pig serum (GPS). The alkaloid fractions, containing quaternary alkaloids expressed suppressive effect on mitogen-induced splenocyte proliferation. The in vitro antibody response against sheep red blood cells (anti-SRBC) was inhibited by ethanol extracts and quaternary alkaloid fraction. The intraperitoneal (i.p.) application of ethanol extract and tertiary alkaloid fraction from aerial parts showed that they possess in vivo effect on alternative pathway (AP) complement activity, anti-SRBC response and delayed type hypersensitivity (DTH).
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(96)01462-6