Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa

This study investigated the ET A and ET B receptor subtypes in rat adrenal cortex. The ET A antagonist, BQ-123, inhibited the zona glomerulosa (zg), but not the inner zone (iz) response to ET-1. RES-701-1, the ET B antagonist, abolished the iz response to ET-1, but had less effect on the zg. [ 125I]...

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Bibliographic Details
Published in:FEBS letters 1996-11, Vol.397 (2), p.186-190
Main Authors: Kapas, S., Cameron, L.A., Puddefoot, J.R., Hinson, J.P.
Format: Article
Language:English
Subjects:
Adrenal
Adrenocorticotropic Hormone - pharmacology
Aldosterone
Aldosterone - metabolism
Angiotensin II - pharmacology
Animals
Corticosterone
Corticosterone - metabolism
Endothelin receptor
Endothelin Receptor Antagonists
Endothelin-1 - metabolism
Endothelin-1 - pharmacology
Female
Male
Peptides, Cyclic - pharmacology
Rats
Rats, Wistar
Receptor, Endothelin A
Receptor, Endothelin B
Receptors, Endothelin - metabolism
Zona Fasciculata - metabolism
Zona glomerulosa
Zona Glomerulosa - metabolism
Zona Reticularis - metabolism
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Summary:This study investigated the ET A and ET B receptor subtypes in rat adrenal cortex. The ET A antagonist, BQ-123, inhibited the zona glomerulosa (zg), but not the inner zone (iz) response to ET-1. RES-701-1, the ET B antagonist, abolished the iz response to ET-1, but had less effect on the zg. [ 125I]ET-1 binding studies revealed two receptor subtypes in both zones, with ET A predominating in the zg, and ETB in the iz. These data suggest that the ET A subtype is functionally more important in the zg while the ET B receptor is the major subtype in the inner zones.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(96)01133-7