Tandem triplication and quadruplication of chromosome 21 in childhood acute lymphoblastic leukemia

A 5-year-old girl with ALL was shown to have a leukemic clone characterized by a triplication and quadruplication of chromosome 21, arranged in tandem, at diagnosis and relapse, respectively. To our knowledge, this is the second report of this chromosomal anomaly in ALL, which was confirmed by in si...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 1996-11, Vol.92 (1), p.43-45
Main Authors: Baialardo, Edgardo M., Felice, María S., Rossi, Jorge, Barreiro, Cristina, Gallego, Marta S.
Format: Article
Language:English
Subjects:
Aneuploidy
Biological and medical sciences
Child, Preschool
Chromosomes, Human, Pair 21 - genetics
Female
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Trisomy - genetics
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Summary:A 5-year-old girl with ALL was shown to have a leukemic clone characterized by a triplication and quadruplication of chromosome 21, arranged in tandem, at diagnosis and relapse, respectively. To our knowledge, this is the second report of this chromosomal anomaly in ALL, which was confirmed by in situ staining. The karyotype evolution in the leukemic clone from triplication to quadruplication at relapse emphasis the association of chromosome 21 with hematopoietic malignancies.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(96)00151-3