Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease

We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph no...

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Bibliographic Details
Published in:European journal of pediatrics 1996-12, Vol.155 (12), p.1015-1017
Main Authors: DE HEER-GROEN, T. A, PRAKKEN, A. B. J, BAX, N. M. A, VAN DIJKEN, P. J
Format: Article
Language:English
Subjects:
Adolescent
Anemia - drug therapy
Anemia - etiology
Anemias. Hemoglobinopathies
Biological and medical sciences
Castleman Disease - diagnosis
Castleman Disease - physiopathology
Castleman Disease - surgery
Diseases of red blood cells
Female
Hematologic and hematopoietic diseases
Humans
Iron - therapeutic use
Medical sciences
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Summary:We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely. Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF02532521